II-nd Department of Otolaryngology, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Street Republicii No. 18, 400015 Cluj-Napoca, Romania.
Biomed Res Int. 2013;2013:101534. doi: 10.1155/2013/101534. Epub 2013 Oct 28.
It is acknowledged that many causes of failures in endoscopic sinus surgery are related to scarring and narrowing of the maxillary antrostomy. We assessed the effect of low-pressure spray cryotherapy in preventing the maxillary antrostomy stenosis in a chronic rhinosinusitis (CRS) rabbit model. A controlled, randomized, double-blind study was conducted on 22 New Zealand rabbits. After inducing unilateral rhinogenic CRS, a maxillary antrostomy was performed and spray cryotherapy was employed on randomly selected 12 rabbits, while saline solution was applied to the control group (n = 10). The antrostomy dimensions and the histological scores were assessed 4 weeks postoperatively. The diameter of cryotreated antrostomy was significantly larger at 4 weeks than that in the control group. At 4 weeks, the maxillary antrostomy area in the study group was significantly larger than the mean area in the control group (103.92 ± 30.39 mm² versus 61.62 ± 28.35 mm², P = 0.002). Submucosal fibrous tissues and leukocytic infiltration in saline-treated ostia were more prominent than those in cryotreated ostia with no significant differences between the two groups regarding the histological scores. Intraoperative low-pressure spray cryotherapy increases the patency of the maxillary antrostomy at 4 weeks postoperatively with no important local side effects.
人们承认，许多鼻窦内窥镜手术失败的原因与上颌窦口的瘢痕和狭窄有关。我们评估了低压喷雾冷冻疗法在预防慢性鼻-鼻窦炎（CRS）兔模型上颌窦口狭窄中的作用。对 22 只新西兰兔进行了一项对照、随机、双盲研究。在诱导单侧鼻源性 CRS 后，进行上颌窦造口术，随机选择 12 只兔行喷雾冷冻治疗，对照组（n = 10）给予生理盐水。术后 4 周评估窦口尺寸和组织学评分。冷冻治疗后 4 周，窦口直径明显大于对照组。4 周时，研究组上颌窦口面积明显大于对照组的平均面积（103.92 ± 30.39mm² 比 61.62 ± 28.35mm²，P = 0.002）。与冷冻治疗窦口相比，生理盐水处理窦口的黏膜下纤维组织和白细胞浸润更为明显，但两组间组织学评分无显著差异。术中低压喷雾冷冻治疗可增加术后 4 周上颌窦口的通畅性，且无重要的局部副作用。
