Reutens Anne T, Balkau Beverley, Cohen Neale
1 Baker IDI Heart and Diabetes Institute , Melbourne, Victoria, Australia .
Diabetes Technol Ther. 2014 Apr;16(4):235-40. doi: 10.1089/dia.2013.0250. Epub 2013 Nov 28.
Jet injectors allow needle-free insulin delivery. The study objective was to compare the tolerability and device preference of subcutaneous insulin aspart delivery by jet injector (InsuJet™; European Pharma Group, Schiphol-Rijk, The Netherlands) with pen injection in an open-label, randomized, crossover pilot study.
Ten participants with type 1 diabetes underwent two meal tolerance tests 1 week apart. Plasma glucose and serum insulin levels were sampled from 10 min preceding to 240 min after insulin aspart administration by InsuJet or FlexPen(®) (Novo Nordisk Pharmaceuticals Pty. Ltd., Baulkham Hills, NSW, Australia). Insulin dose was calculated using participants' insulin-to-carbohydrate ratios. Immediately after insulin administration, participants drank 500 mL of Ensure(®) (Abbott Australasia Pty. Ltd., Botany, NSW, Australia) (providing 2,240 kJ of energy, 18.6 g of protein, 96 g of carbohydrate, and 3 g of fat).
In this small pilot study, the devices were similar in glucose excursion (median [quartile 1, quartile 3], InsuJet vs. FlexPen, 9.4 [4.8, 12.8] vs. 8.1 [5.4, 10.6] mmol/L; P=0.43), in the area under the glucose concentration-time curve for 0-240 min corrected for baseline glucose level (InsuJet vs. FlexPen, 1,230 [623, 2,012] vs. 1,175 [91, 1,774] mmol · min/L; P=0.4), and in insulin absorption over the 240-min period. Devices were similar for participant preference and relative injection pain.
Subcutaneous jet injection of aspart insulin was well tolerated.
喷射注射器可实现无针胰岛素注射。本研究的目的是在一项开放标签、随机、交叉试点研究中，比较喷射注射器（InsuJet™；欧洲制药集团，荷兰史基浦 - 里耶克）与笔式注射皮下注射门冬胰岛素的耐受性和设备偏好。
10名1型糖尿病患者，间隔1周进行两次进餐耐量试验。在通过InsuJet或优伴笔（FlexPen®）（诺和诺德制药私人有限公司，澳大利亚新南威尔士州鲍尔克姆山）给予门冬胰岛素前10分钟至给药后240分钟期间采集血浆葡萄糖和血清胰岛素水平样本。胰岛素剂量根据参与者的胰岛素 - 碳水化合物比例计算。胰岛素给药后，参与者立即饮用500毫升安素（Ensure®）（雅培澳大利亚私人有限公司，澳大利亚新南威尔士州博特尼）（提供2240千焦能量、18.6克蛋白质、96克碳水化合物和3克脂肪）。
在这项小型试点研究中，两种设备在血糖波动方面相似（中位数[四分位数1，四分位数3]，InsuJet与优伴笔，9.4[4.8，12.8]与8.1[5.4，10.6]毫摩尔/升；P = 0.43），在根据基线血糖水平校正的0 - 240分钟葡萄糖浓度 - 时间曲线下面积方面相似（InsuJet与优伴笔，1230[623，2012]与1175[91，1774]毫摩尔·分钟/升；P = 0.4），以及在240分钟期间的胰岛素吸收方面相似。两种设备在参与者偏好和相对注射疼痛方面相似。
皮下喷射注射门冬胰岛素耐受性良好。
