Guo Lixin, Xiao Xinhua, Sun Xue, Qi Cuijuan
Department of Endocrinology, Beijing Hospital Department of Endocrinology, Peking Union Medical College Hospital, Beijing, China.
Medicine (Baltimore). 2017 Jan;96(1):e5482. doi: 10.1097/MD.0000000000005482.
This study is conducted to investigate efficacy of an insulin jet injector and an insulin pen in treatment of type 2 diabetic patients. Sixty patients with type 2 diabetes were treated with rapid-acting insulin (regular insulin) and insulin analog (insulin aspart) using the jet injector and the pen in 4 successive test cycles. Postprandial glucose and insulin concentrations in blood were measured over time. Areas under curves of glucose and the insulin were calculated, and efficacy of 2 injection methods in treatment of the diabetes was compared. Regular insulin and insulin aspart administration by the jet injector showed significant decreases in plasma glucose levels as compared to the pen injection (P < 0.05). Postprandial plasma glucose excursions at the time points of 0.5 to 3 hours were obviously lower in the jet-treated patients than the pen-treated ones (P < 0.05). Postprandial plasma insulin levels were markedly higher in the jet-treated patients than the pen-treated ones (P < 0.05). Area under the glucose curve in the pen-treated patients was significantly increased as compared to the jet-treated ones (P < 0.01). Efficacy of the insulin jet injector in treatment of type 2 diabetic patients is obviously superior to the insulin pen in regulating plasma glucose and insulin levels.
本研究旨在探讨胰岛素喷射注射器和胰岛素笔治疗2型糖尿病患者的疗效。60例2型糖尿病患者在4个连续的测试周期中使用喷射注射器和胰岛素笔接受速效胰岛素（普通胰岛素）和胰岛素类似物（门冬胰岛素）治疗。随时间测量餐后血糖和血液中的胰岛素浓度。计算血糖和胰岛素的曲线下面积，并比较两种注射方法治疗糖尿病的疗效。与胰岛素笔注射相比，喷射注射器注射普通胰岛素和门冬胰岛素后血浆葡萄糖水平显著降低（P<0.05）。在0.5至3小时时间点，喷射治疗患者的餐后血浆葡萄糖波动明显低于胰岛素笔治疗患者（P<0.05）。喷射治疗患者的餐后血浆胰岛素水平明显高于胰岛素笔治疗患者（P<0.05）。与喷射治疗患者相比，胰岛素笔治疗患者的血糖曲线下面积显著增加（P<0.01）。胰岛素喷射注射器治疗2型糖尿病患者在调节血浆葡萄糖和胰岛素水平方面的疗效明显优于胰岛素笔。
