Hill Matthew N, Patel Sachin
Hotchkiss Brain Institute, Departments of Cell Biology & Anatomy and Psychiatry, University of Calgary, 3330 Hospital Drive NW, Calgary AB T2N4N1, Canada.
Biol Mood Anxiety Disord. 2013 Oct 22;3(1):19. doi: 10.1186/2045-5380-3-19.
Accumulating evidence over the past decade has highlighted an important role of the endocannabinoid (eCB) system in the regulation of stress and emotional behavior across divergent species, from rodents to humans. The general findings from this work indicate that the eCB system plays an important role in gating and buffering the stress response, dampening anxiety and regulating mood. Work in rodents has allowed researchers to determine the neural mechanisms mediating this relationship while work in human populations has demonstrated the possible importance of this system in stress-related psychiatric diseases, such as post-traumatic stress disorder, generalized anxiety and major depression. These stress-protective effects of eCB signaling appear to be primarily mediated by their actions within corticolimbic structures, particularly the amygdala and the prefrontal cortex. The aim of this review is to provide an up-to-date discussion of the current level of knowledge in this field, as well as address the current gaps in knowledge and specific areas of research that require attention.
在过去十年中，越来越多的证据凸显了内源性大麻素（eCB）系统在调节从啮齿动物到人类等不同物种的应激和情绪行为方面的重要作用。这项研究的总体结果表明，eCB系统在控制和缓冲应激反应、减轻焦虑以及调节情绪方面发挥着重要作用。对啮齿动物的研究使研究人员能够确定介导这种关系的神经机制，而对人类群体的研究则证明了该系统在创伤后应激障碍、广泛性焦虑症和重度抑郁症等与应激相关的精神疾病中的潜在重要性。eCB信号的这些应激保护作用似乎主要是通过它们在皮质边缘结构（特别是杏仁核和前额叶皮质）中的作用来介导的。本综述的目的是提供对该领域当前知识水平的最新讨论，并解决当前知识空白以及需要关注的特定研究领域。
