Bay K 8644对血管紧张素II诱导的兔主动脉条收缩的影响。

The effect of Bay K 8644 on angiotensin II-induced contractions of rabbit aortic strips.

作者信息

Roy F, Pruneau D

出版信息

Eur J Pharmacol. 1986 Jul 15;126(1-2):163-6. doi: 10.1016/0014-2999(86)90755-7.

Abstract

The effect of Bay K 8644 on contractile responses to angiotensin II (AII) was investigated in rabbit aorta. Bay K 8644 alone did not elicit contraction while contractile responses to AII were enhanced at low concentrations (10(-8), 3 X 10(-8), 10(-7) M) and depressed at a higher concentration (10(-6) M). The potentiating effect was always observed and increased after treatment by phentolamine. These findings suggest that Bay K 8644 activates calcium channels operated by angiotensin receptors.

摘要

研究了Bay K 8644对兔主动脉中血管紧张素II（AII）收缩反应的影响。单独使用Bay K 8644不会引起收缩，而在低浓度（10^(-8)、3×10^(-8)、10^(-7) M）时对AII的收缩反应增强，在高浓度（10^(-6) M）时则受到抑制。酚妥拉明处理后始终观察到增强作用且增强作用增加。这些发现表明Bay K 8644激活了由血管紧张素受体操控的钙通道。