Bay K 8644可诱导单个心肌细胞和平滑肌细胞中的钾离子电流增强。
Bay K 8644 induce enhancement of K+ current in both single heart cell and smooth muscle cell.
作者信息
Renaud J F, Bkaily G, Benabderrazik M, Jacques D, Sperelakis N
机构信息
Fondax, Groupe de Recherches Servier, Puteaux, France.
出版信息
Mol Cell Biochem. 1988 Mar-Apr;80(1-2):73-8. doi: 10.1007/BF00231005.
The effects of the Ca2+ agonist Bay K 8644 on outward potassium currents have been studied in single ventricular cells of chick embryo and aortic single cells of rabbit using the whole-cell patch clamp technique. Bay K 8644 was found to increase 1K in both heart and aortic single cells. This effect of Bay K 8644 on both muscle was reversed by Mn2+ and blocked by 20 mM TEA. The Bay K 8644 potassium I/V curve of single heart cell had a N shape, which is Ca2+ dependent. These data strongly suggest that Bay K 8644 increases a gK(Ca) in both aortic and heart muscle.
运用全细胞膜片钳技术，在鸡胚单个心室细胞和兔主动脉单个细胞中研究了钙离子激动剂Bay K 8644对外向钾电流的影响。研究发现，Bay K 8644可使心脏和主动脉单个细胞中的IK增加。Mn2+可逆转Bay K 8644对这两种肌肉的这种作用，且20 mM四乙铵（TEA）可阻断该作用。单个心脏细胞的Bay K 8644钾电流-电压（I/V）曲线呈N形，这依赖于钙离子。这些数据有力地表明，Bay K 8644可增加主动脉和心肌中的gK（Ca）。
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