Iovanna J, Giorgi D, Dagorn J C
Digestion. 1986;34(3):178-84. doi: 10.1159/000199327.
The rates of intracellular transport of newly synthesized amylase, lipase, trypsinogen and chymotrypsinogen were compared in the anaesthesized rat pancreas by measuring their rates of secretion while keeping their relative rates of synthesis in a steady state. It is concluded that pancreatic proteins are not transported all at the same rate through the acinar cell. Among the four enzymes studied, proteolytic enzymes are transported faster than lipase, and amylase is the slowest. The relative rates of transport of these enzymes are not altered by secretory stimulation, since similar results were obtained in the basal state and under constant caerulein infusion (300 ng/kg/h).
通过在麻醉大鼠胰腺中测量新合成的淀粉酶、脂肪酶、胰蛋白酶原和糜蛋白酶原的分泌速率，同时使它们的相对合成速率保持稳定状态，比较了这些酶的细胞内运输速率。得出的结论是，胰腺蛋白质在腺泡细胞中的运输速率并非全都相同。在所研究的四种酶中，蛋白水解酶的运输速度比脂肪酶快，而淀粉酶最慢。这些酶的相对运输速率不会因分泌刺激而改变，因为在基础状态和持续输注雨蛙肽（300 ng/kg/h）的情况下获得了相似的结果。
