Ahmed R M, Zmudzki F, Parker G D, Owler B K, Halmagyi G M
From the Departments of Neurology (R.A., G.M.H.).
Époque Consulting (F.Z.), Sydney, Australia.
AJNR Am J Neuroradiol. 2014 May;35(5):952-8. doi: 10.3174/ajnr.A3806. Epub 2013 Nov 28.
Transverse sinus venous stent placement has been shown to lower intracranial pressure in patients with venogenic pseudotumor cerebri and to reverse, or at least stabilize, its symptoms and signs. There have been no studies comparing the cost of venous stenting with the time-honored treatment for pseudotumor cerebri-CSF shunting. The purpose of this study was to compare the cost of trasverse sinus stenting versus CSF shunting for the treatment of pseudotumor cerebri.
This work was a retrospective cost analysis of individual resource use in 86 adults who were stented for pseudotumor cerebri during a 12-year period compared with resource use in 110 children who were shunted for hydrocephalus during a 3-year period.
There was no significant difference between the cost of inserting an initial venous stent ($13,863 ± 4890) versus inserting an initial CSF shunt ($15,797 ± 5442) (P = .6337) or between inserting an additional venous stent ($9421 ± 69) versus revising a CSF shunt ($10,470 ± 1245) (P = .4996). There were far fewer additional venous stent insertions per patient than there were subsequent CSF shunt revisions; 87% of stents placed required just 1 stent procedure, whereas only 45% of shunts required 1 shunt procedure. The main cause of the cost difference was the need for repeated revisions of the shunts, especially when they became infected-24 instances of a total 143 shunt procedures (16.8%) at an average cost of $84,729, approximately 5 times the cost of an initial shunt insertion.
Venous stenting costs significantly less per 100 procedures than does CSF shunting, due largely to the high cost of treating shunt infections and the need for repeated shunt revisions.
已证实横窦静脉支架置入术可降低静脉性假性脑瘤患者的颅内压,并使其症状和体征得到逆转或至少稳定下来。尚无研究比较静脉支架置入术与治疗假性脑瘤的传统方法——脑脊液分流术的成本。本研究的目的是比较横窦支架置入术与脑脊液分流术治疗假性脑瘤的成本。
本研究是一项回顾性成本分析,比较了12年间86例接受假性脑瘤支架置入术的成年患者的个体资源使用情况与3年间110例接受脑积水分流术的儿童的资源使用情况。
置入首个静脉支架的成本(13,863美元±4890美元)与置入首个脑脊液分流管的成本(15,797美元±5442美元)之间无显著差异(P = 0.6337),置入额外静脉支架的成本(9421美元±69美元)与修订脑脊液分流管的成本(10,470美元±1245美元)之间也无显著差异(P = 0.4996)。每位患者额外置入静脉支架的次数远少于后续修订脑脊液分流管的次数;所置入支架中有87%仅需进行1次支架手术,而分流管中只有45%只需进行1次分流手术。成本差异的主要原因是需要反复修订分流管,尤其是当分流管发生感染时——在总共143次分流手术中有24例(16.8%),平均成本为84,729美元,约为首次置入分流管成本的5倍。
每100例手术中,静脉支架置入术的成本显著低于脑脊液分流术,这主要是由于治疗分流管感染的成本高昂以及需要反复修订分流管。