Santos H B de P, Silva A L do Ó, Cavalcante L H de A, Alves P M, Godoy G P, Nonaka C F W
School of Dentistry, State University of Paraíba, Campina Grande, PB, Brazil.
Postgraduate Program in Dentistry, State University of Paraíba, Campina Grande, PB, Brazil.
Int J Oral Maxillofac Surg. 2014 May;43(5):539-45. doi: 10.1016/j.ijom.2013.10.021. Epub 2013 Nov 27.
The objective of this study was to evaluate the histopathological grade of malignancy in a series of lower lip squamous cell carcinomas (LLSCCs) using three histopathological grading systems (invasive front grading system, World Health Organization (WHO) grading system, and histological risk assessment), and to correlate this with clinical parameters (tumour size/extent, regional lymph node metastasis, and clinical stage). Haematoxylin-eosin-stained histological sections obtained from 59 cases of LLSCC were analyzed by light microscopy. Grading of the invasive tumour front showed a significant association between low grade of malignancy and the absence of regional lymph node metastasis (P=0.030) and initial clinical stage (P=0.043). No significant associations were observed between the clinical parameters analyzed and the WHO system (P>0.05). Using the risk assessment, a highly significant association was observed between the risk score and regional lymph node metastasis (P=0.004) and clinical stage (P=0.002). In addition, the lymphocytic infiltrate was significantly associated with regional lymph node metastasis (P=0.017) and clinical stage (P=0.040). The results of the present study suggest that, among the histopathological grading systems evaluated, the histological risk assessment is the best option to predict the biological behaviour of LLSCCs.
本研究的目的是使用三种组织病理学分级系统（浸润前沿分级系统、世界卫生组织（WHO）分级系统和组织学风险评估）评估一系列下唇鳞状细胞癌（LLSCC）的恶性组织病理学分级，并将其与临床参数（肿瘤大小/范围、区域淋巴结转移和临床分期）相关联。通过光学显微镜分析从59例LLSCC获得的苏木精-伊红染色组织切片。浸润性肿瘤前沿的分级显示低恶性程度与无区域淋巴结转移（P=0.030）和初始临床分期（P=0.043）之间存在显著关联。在所分析的临床参数与WHO系统之间未观察到显著关联（P>0.05）。使用风险评估，观察到风险评分与区域淋巴结转移（P=0.004）和临床分期（P=0.002）之间存在高度显著关联。此外，淋巴细胞浸润与区域淋巴结转移（P=0.017）和临床分期（P=0.040）显著相关。本研究结果表明，在所评估的组织病理学分级系统中，组织学风险评估是预测LLSCC生物学行为的最佳选择。
