Daniele E, Rodolico V, Leonardi V, Tralongo V
Cattedra di Istituzioni di Anatomia Patologica, University of Palermo, Italy.
Pathol Res Pract. 1998;194(5):319-24. doi: 10.1016/S0344-0338(98)80055-1.
We studied a consecutive series of 54 cases of lower lip squamous cell carcinoma (LLSCC) in order to identify any variables which might predict the development of lymph node metastases. The cases were divided into 38 tumors without metastases (group I) and 16 tumors with lymph node metastases (group II). The following factors were investigated: tumor size, histologic grading maximal thickness, perineural invasion, DNA ploidy and PCNA expression. In conclusion, we found that LLSCC greater than 2 cm in diameter, with histological grading G3-G4, thickness of more than 6 mm, DNA aneuploidy and high PCNA expression (PCNA LI > 0.48), were at high risk for the development of lymph node metastases.
我们研究了连续的54例下唇鳞状细胞癌（LLSCC）病例，以确定任何可能预测淋巴结转移发生的变量。这些病例分为38例无转移的肿瘤（I组）和16例有淋巴结转移的肿瘤（II组）。研究了以下因素：肿瘤大小、组织学分级、最大厚度、神经周围浸润、DNA倍体和PCNA表达。总之，我们发现直径大于2 cm、组织学分级为G3 - G4、厚度超过6 mm、DNA非整倍体和PCNA高表达（PCNA LI > 0.48）的LLSCC发生淋巴结转移的风险较高。
