College of Science and Engineering, University of Minnesota, Minneapolis, Minnesota; Department of Diagnostic and Interventional Radiology, Cairo University, Cairo, Egypt.
College of Science and Engineering, University of Minnesota, Minneapolis, Minnesota.
Fertil Steril. 2014 Feb;101(2):545-51. doi: 10.1016/j.fertnstert.2013.10.023. Epub 2013 Nov 26.
To investigate the feasibility of using high-intensity focused ultrasound (HIFU), under dual-mode ultrasound arrays (DMUAs) guidance, to induce localized thermal damage inside ovaries without damage to the ovarian surface.
Laboratory feasibility study.
University-based laboratory.
ANIMAL(S): Ex vivo canine and bovine ovaries.
INTERVENTION(S): DMUA-guided HIFU.
MAIN OUTCOME MEASURE(S): Detection of ovarian damage by ultrasound imaging, gross pathology, and histology.
RESULT(S): It is feasible to induce localized thermal damage inside ovaries without damage to the ovarian surface. DMUA provided sensitive imaging feedback regarding the anatomy of the treated ovaries and the ablation process. Different ablation protocols were tested, and thermal damage within the treated ovaries was histologically characterized.
CONCLUSION(S): The absence of damage to the ovarian surface may eliminate many of the complications linked to current laparoscopic ovarian drilling (LOD) techniques. HIFU may be used as a less traumatic tool to perform LOD.
研究在双模式超声阵列（DMUA）引导下使用高强度聚焦超声（HIFU）在不损伤卵巢表面的情况下在卵巢内产生局部热损伤的可行性。
实验室可行性研究。
大学实验室。
离体犬和牛卵巢。
DMUA 引导的 HIFU。
超声成像、大体病理和组织学检测卵巢损伤。
在不损伤卵巢表面的情况下，在卵巢内产生局部热损伤是可行的。DMUA 对治疗卵巢的解剖结构和消融过程提供了敏感的成像反馈。测试了不同的消融方案，并对治疗卵巢内的热损伤进行了组织学特征描述。
不损伤卵巢表面可能消除与当前腹腔镜卵巢钻孔（LOD）技术相关的许多并发症。HIFU 可作为一种创伤较小的工具来进行 LOD。
