Division of Rheumatology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sport, University of Sao Paulo, Av. Prof. Mello de Moraes 65, Sao Paulo, SP 05508-030, Brazil.
Br J Nutr. 2014 Apr 14;111(7):1272-4. doi: 10.1017/S0007114513003802. Epub 2013 Nov 29.
The present cross-sectional study aimed to examine the influence of diet on brain creatine (Cr) content by comparing vegetarians with omnivores. Brain Cr content in the posterior cingulate cortex was assessed by proton magnetic resonance spectroscopy (¹H-MRS). Dietary Cr intake was assessed by 3 d food recalls. Vegetarians had lower dietary Cr intake than omnivores (0.03 (SD 0.01) v. 1.34 (SD 0.62) g/d, respectively; P=0.005). However, vegetarians and omnivores had comparable brain total Cr content (5.999 (SD 0.811) v. 5.917 (SD 0.665) IU, respectively; P=0.77). In conclusion, dietary Cr did not influence brain Cr content in healthy individuals, suggesting that in normal conditions brain is dependent on its own Cr synthesis.
本横断面研究旨在通过比较素食者和杂食者来研究饮食对大脑肌酸（Cr）含量的影响。通过质子磁共振波谱（1H-MRS）评估后扣带回皮质的脑 Cr 含量。通过 3 天的食物回忆评估饮食 Cr 摄入量。素食者的饮食 Cr 摄入量低于杂食者（分别为 0.03（SD 0.01）v. 1.34（SD 0.62）g/d；P=0.005）。然而，素食者和杂食者的大脑总 Cr 含量相当（分别为 5.999（SD 0.811）v. 5.917（SD 0.665）IU；P=0.77）。总之，饮食 Cr 并未影响健康个体的大脑 Cr 含量，这表明在正常情况下，大脑依赖于自身的 Cr 合成。
