Department of Mechanical Engineering, University College London, WC1E 7JE, UK.
University College London Hospital, NW1 2BU, UK.
Med Eng Phys. 2014 Mar;36(3):275-84. doi: 10.1016/j.medengphy.2013.11.003. Epub 2013 Nov 26.
Aortic dissection has high morbidity and mortality rates and guidelines regarding surgical intervention are not clearly defined. The treatment of aortic dissection varies with each patient and detailed knowledge of haemodynamic and mechanical forces would be advantageous in the process of choosing a course of treatment. In this study, a patient-specific dissected aorta geometry is constructed from computed tomography scans. Dynamic boundary conditions are implemented by coupling a three element Windkessel model to the 3D domain at each outlet, in order to capture the essential behaviour of the downstream vasculature. The Windkessel model parameters are defined based on clinical data. The predicted minimum and maximum pressures are close to those measured invasively. Malperfusion is indicated and complex flow patterns are observed. Pressure, flow and wall shear stress distributions are analysed. The methodology presented here provides insight into the haemodynamics in a patient-specific dissected aorta and represents a development towards the use of CFD simulations as a diagnostic tool for aortic dissection.
主动脉夹层的发病率和死亡率都很高，关于手术干预的指南也没有明确界定。主动脉夹层的治疗因患者而异，详细了解血流动力学和力学因素将有助于选择治疗方案。在这项研究中，从计算机断层扫描构建了一个特定于患者的夹层主动脉几何形状。通过在每个出口处将一个三元素风箱模型与 3D 域耦合，实现动态边界条件，以捕获下游血管的基本行为。风箱模型参数根据临床数据定义。预测的最小和最大压力接近侵入性测量值。指示灌注不足并观察到复杂的流动模式。分析压力、流量和壁面切应力分布。这里提出的方法提供了对特定于患者的夹层主动脉中血液动力学的深入了解，并代表了将 CFD 模拟用作主动脉夹层诊断工具的发展。
