Prickaerts Jos, Gieling Elise T, Bruder Ann K, van der Staay Franz J, Vanmierlo Tim
Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine and Life Science, Maastricht University, Universiteitssingel 50, 6229ER Maastricht, The Netherlands.
Emotion & Cognition Group, Department of Farm Animal Health, Faculty of Veterinary Medicine, University Utrecht, P.O. Box 80151, Utrecht, The Netherlands; Rudolf Magnus Institute of Neuroscience, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.
Int J Dev Neurosci. 2014 Apr;33:29-32. doi: 10.1016/j.ijdevneu.2013.11.001. Epub 2013 Nov 26.
In this study, we investigated the effect of antenatal allopurinol (ALLO) treatment on levels and expression of plasticity markers in the dorsal hippocampus of low (LBW) and normal (NBW) birth weight piglets. ALLO treatment given daily in the last trimester to pregnant sows had a protective effect on neuronal plasticity markers in their piglets. ALLO increases protein levels of BDNF and the postsynaptic marker PSD95 in LBW and NBW piglets. ALLO treatment increases the pCREB/CREB ratio in LBW piglets to a similar level as that found in untreated NBW piglets. In conclusion, antioxidant treatment administered in the last trimester might be a promising treatment for LBW neonates.
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