Yasin Rahima, Jiang Li, Das Jai K, Bhutta Zulfiqar A
Institute for Global Health and Development, The Aga Khan University, Karachi, Pakistan.
Center for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.
Neonatology. 2025;122(Suppl 1):32-41. doi: 10.1159/000543690. Epub 2025 Jan 28.
Care interventions aimed at preventing and treating maternal infections during the gestational period are of paramount importance. Timely immunizations, screening strategies, and management of maternal infections reduce the risk of complications for the developing fetus and play a pivotal role in improving neonatal outcomes.
We aim to summarize evidence for a total of thirteen interventions, pertaining to the prevention and treatment of maternal infections during the antenatal period, from Every Newborn Series published in The Lancet 2014. We identified the most recent systematic reviews, extracted data from each review, and conducted a sub-group meta-analysis for low-income countries and lower-middle-income countries (LMICs) for outcomes relevant to neonatal health. Findings from our papers indicate limited evidence from LMICs, highlighting the pressing need for coordinated efforts to close this gap and strengthen the body of inclusive evidence on prevention and treatment of maternal infections during pregnancy.
Evidence from LMICs suggests that influenza virus vaccination had no effect on stillbirth, preterm birth, small for gestational age, or low birthweight (LBW). Insecticide-treated bed nets in pregnancy reduced the risk of fetal loss and improved the babies' birthweight. Changing a two-dose intermittent preventive treatment (IPTp) regimen to more frequent IPTp dosing decreased the risk of LBW and significantly improved babies' birthweight. Addition of antibacterial antibiotic to the IPTp regimen significantly reduced the risk of LBW. Antibiotic treatments for syphilis and chlamydia had a significant effect on LBW. Treatment of documented periodontal disease during pregnancy reduced the risk of LBW.
Care interventions aimed at preventing and treating maternal infections during the gestational period are of paramount importance. Timely immunizations, screening strategies, and management of maternal infections reduce the risk of complications for the developing fetus and play a pivotal role in improving neonatal outcomes.
We aim to summarize evidence for a total of thirteen interventions, pertaining to the prevention and treatment of maternal infections during the antenatal period, from Every Newborn Series published in The Lancet 2014. We identified the most recent systematic reviews, extracted data from each review, and conducted a sub-group meta-analysis for low-income countries and lower-middle-income countries (LMICs) for outcomes relevant to neonatal health. Findings from our papers indicate limited evidence from LMICs, highlighting the pressing need for coordinated efforts to close this gap and strengthen the body of inclusive evidence on prevention and treatment of maternal infections during pregnancy.
Evidence from LMICs suggests that influenza virus vaccination had no effect on stillbirth, preterm birth, small for gestational age, or low birthweight (LBW). Insecticide-treated bed nets in pregnancy reduced the risk of fetal loss and improved the babies' birthweight. Changing a two-dose intermittent preventive treatment (IPTp) regimen to more frequent IPTp dosing decreased the risk of LBW and significantly improved babies' birthweight. Addition of antibacterial antibiotic to the IPTp regimen significantly reduced the risk of LBW. Antibiotic treatments for syphilis and chlamydia had a significant effect on LBW. Treatment of documented periodontal disease during pregnancy reduced the risk of LBW.
旨在预防和治疗孕期母体感染的护理干预至关重要。及时进行免疫接种、筛查策略以及对母体感染的管理可降低发育中胎儿出现并发症的风险，并在改善新生儿结局方面发挥关键作用。
我们旨在总结《柳叶刀》2014年发表的《每一个新生儿系列》中有关产前预防和治疗母体感染的总共13项干预措施的证据。我们确定了最新的系统评价，从每项评价中提取数据，并针对低收入国家和中低收入国家（LMICs）进行了与新生儿健康相关结局的亚组荟萃分析。我们论文的研究结果表明，来自LMICs的证据有限，这凸显了迫切需要共同努力来填补这一差距，并加强关于孕期预防和治疗母体感染的包容性证据体系。
来自LMICs的证据表明，流感病毒疫苗接种对死产、早产、小于胎龄儿或低出生体重（LBW）没有影响。孕期使用经杀虫剂处理的蚊帐可降低胎儿丢失风险并提高婴儿出生体重。将两剂间歇性预防治疗（IPTp）方案改为更频繁的IPTp给药可降低LBW风险并显著提高婴儿出生体重。在IPTp方案中添加抗菌抗生素可显著降低LBW风险。梅毒和衣原体的抗生素治疗对LBW有显著影响。孕期治疗已确诊的牙周疾病可降低LBW风险。
旨在预防和治疗孕期母体感染的护理干预至关重要。及时进行免疫接种、筛查策略以及对母体感染的管理可降低发育中胎儿出现并发症的风险，并在改善新生儿结局方面发挥关键作用。
我们旨在总结《柳叶刀》2014年发表的《每一个新生儿系列》中有关产前预防和治疗母体感染的总共13项干预措施的证据。我们确定了最新的系统评价，从每项评价中提取数据，并针对低收入国家和中低收入国家（LMICs）进行了与新生儿健康相关结局的亚组荟萃分析。我们论文的研究结果表明，来自LMICs的证据有限，这凸显了迫切需要共同努力来填补这一差距，并加强关于孕期预防和治疗母体感染的包容性证据体系。
来自LMICs的证据表明，流感病毒疫苗接种对死产、早产、小于胎龄儿或低出生体重（LBW）没有影响。孕期使用经杀虫剂处理的蚊帐可降低胎儿丢失风险并提高婴儿出生体重。将两剂间歇性预防治疗（IPTp）方案改为更频繁的IPTp给药可降低LBW风险并显著提高婴儿出生体重。在IPTp方案中添加抗菌抗生素可显著降低LBW风险。梅毒和衣原体的抗生素治疗对LBW有显著影响。孕期治疗已确诊的牙周疾病可降低LBW风险。
