丁型肝炎病毒拥有一种环状RNA。

The hepatitis delta (delta) virus possesses a circular RNA.

作者信息

Kos A, Dijkema R, Arnberg A C, van der Meide P H, Schellekens H

出版信息

Nature. 1986;323(6088):558-60. doi: 10.1038/323558a0.

Abstract

Hepatitis delta (delta) virus (HDV), a satellite virus of the hepatitis B virus (HBV), causes a severe form of viral hepatitis in humans. Here we present evidence based on electron microscopy and electrophoretic behaviour that HDV contains a single stranded circular RNA molecule. This is the first animal virus identified with a circular RNA genome. Circular RNAs have only been found in plant viruses. We have obtained a partial complementary DNA clone representing approximately 25% of the total genome of HDV. Analysis of this cDNA revealed similarity to two plant viruses that may explain the origin of the virus.

摘要

丁型肝炎病毒（HDV）是乙型肝炎病毒（HBV）的卫星病毒，可导致人类严重的病毒性肝炎。在此，我们基于电子显微镜和电泳行为提供证据，表明HDV含有一个单链环状RNA分子。这是首个被鉴定出具有环状RNA基因组的动物病毒。环状RNA仅在植物病毒中被发现。我们获得了一个部分互补DNA克隆，其代表了HDV总基因组的约25%。对该cDNA的分析揭示了其与两种植物病毒的相似性，这可能解释了该病毒的起源。