Department of Clinical Sciences, Center for Primary Health Care Research, Lund University, Malmö, Sweden and Region Skåne, Sweden.
BMJ Open. 2013 Nov 29;3(11):e003473. doi: 10.1136/bmjopen-2013-003473.
To investigate the associations between cytokines and insulin sensitivity in Swedish residents born in Iraq and Swedish residents born in Sweden.
Cross-sectional study.
Iraqi and Swedish origin residents of Rosengård area of Malmö, aged 45-65 years, were randomly selected from the census register.
PARTICIPANTS/METHODS: 194 (Iraqi, n=107; Swedish, n=87) participants agreed to participate in the study. Nineteen participants dropped out (Iraqi, n=11; Swedish, n=8). Participants who had already been diagnosed with type 2 diabetes mellitus (T2DM), those who could not participate in an oral glucose tolerance test and those who had a cold/fever at the time of blood sampling were excluded. In total, serum samples from 135 individuals of Swedish (n=62) and Iraqi (n=73) origin were included. Serum concentrations of a panel of 10 cytokines, comprising interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12 (p70), IL-13, interferon-γ and tumour necrosis factor-α were analysed by Luminex multiplex assay.
In the whole study population, levels of all tested cytokines were inversely associated with insulin sensitivity index (ISI), independent of age, sex, body mass index (BMI), sedentary lifestyle and family history of T2DM (p ≤ 0.05). Interestingly, stratification of the study population according to country of birth showed a significant inverse association between all tested cytokines and ISI in the Iraqi-born population (p ≤ 0.01). The association was independent of age, sex, BMI, sedentary lifestyle and family history of T2DM. In contrast, with the exception for IL-6 (p=0.05), no other tested cytokine was found to be significantly associated with ISI in the Swedish-born population (p≥0.05).
Our results show an association between cytokines and ISI in the Iraqi-born population but not in the Swedish-born population.
探讨瑞典出生的伊拉克人和瑞典出生的瑞典人细胞因子与胰岛素敏感性之间的关系。
横断面研究。
从马尔默罗森加德区的人口普查登记册中随机选择年龄在 45-65 岁之间的伊拉克和瑞典原籍居民。
参与者/方法：194 名（伊拉克人，n=107；瑞典人，n=87）参与者同意参加研究。19 名参与者退出（伊拉克人，n=11；瑞典人，n=8）。已被诊断为 2 型糖尿病（T2DM）、无法参加口服葡萄糖耐量试验以及在采血时患有感冒/发烧的参与者被排除在外。共有 135 名瑞典（n=62）和伊拉克（n=73）原籍者的血清样本被纳入研究。通过 Luminex 多重分析检测了 10 种细胞因子（包括白细胞介素 (IL)-1β、IL-2、IL-4、IL-5、IL-6、IL-10、IL-12(p70)、IL-13、干扰素-γ和肿瘤坏死因子-α）的血清浓度。
在整个研究人群中，所有测试的细胞因子水平与胰岛素敏感性指数（ISI）呈负相关，与年龄、性别、体重指数（BMI）、久坐不动的生活方式和 T2DM 家族史无关（p≤0.05）。有趣的是，根据出生地对研究人群进行分层显示，在伊拉克出生的人群中，所有测试的细胞因子与 ISI 呈显著负相关（p≤0.01）。这种关联与年龄、性别、BMI、久坐不动的生活方式和 T2DM 家族史无关。相比之下，除了 IL-6（p=0.05）外，在瑞典出生的人群中，没有其他测试的细胞因子与 ISI 显著相关（p≥0.05）。
我们的结果显示细胞因子与伊拉克出生人群的 ISI 之间存在关联，但与瑞典出生人群无关。
