Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland.
Nat Cell Biol. 2013 Dec;15(12):1398-400. doi: 10.1038/ncb2891.
Calcium enters mitochondria through a dedicated channel referred to as the mitochondrial calcium uniporter (MCU), whose molecular identity has long remained elusive. Since the discovery of the gene encoding the MCU protein two years ago, researchers have awaited the generation of a mouse lacking the MCU. These mice are fully viable and show defects limited to performance of high-energy-demanding exercises. Strikingly, no protection against necrosis is observed following ischaemia-reperfusion in the heart.
钙通过一种称为线粒体钙单向转运体（MCU）的专用通道进入线粒体，其分子身份长期以来一直难以捉摸。自从两年前发现编码 MCU 蛋白的基因以来，研究人员一直在等待生成缺乏 MCU 的小鼠。这些小鼠完全具有活力，并且仅表现出对高能量需求运动的表现缺陷。引人注目的是，在心脏的缺血再灌注后，没有观察到对坏死的保护作用。
