Neumann H A, Runge H M, Fiebig H H, Engelhardt R, Löhr G W
J Cancer Res Clin Oncol. 1986;112(2):165-9. doi: 10.1007/BF00404401.
The cytotoxic effect of bleomycin and peplomycin was compared using a methylcellulose monolayer assay for the cultivation of human tumor cells. In 3 out of 4 samples from human malignant melanomas peplomycin proved to be more cytotoxic than bleomycin. Peplomycin was more cytotoxic than bleomycin in 1 of 5 myosarcoma samples, whereas 2 samples from squamous cell carcinomas of the lung showed identical dose response curves. In 1 carcinoma of the gall bladder peplomycin was more toxic than bleomycin.
使用甲基纤维素单层试验培养人肿瘤细胞，比较了博来霉素和培普利霉素的细胞毒性作用。在来自人类恶性黑色素瘤的4个样本中，有3个样本显示培普利霉素比博来霉素的细胞毒性更强。在5个肉瘤样本中，有1个样本显示培普利霉素比博来霉素的细胞毒性更强，而来自肺鳞状细胞癌的2个样本显示出相同的剂量反应曲线。在1个胆囊癌样本中，培普利霉素比博来霉素的毒性更强。
