博来霉素与培普利欧霉素对源自各种人类肿瘤的克隆形成肿瘤细胞的毒性比较。
Comparison of bleomycin and peplomycin toxicity on clonogenic tumor cells from various human tumors.
作者信息
Neumann H A, Runge H M, Fiebig H H, Engelhardt R, Löhr G W
出版信息
J Cancer Res Clin Oncol. 1986;112(2):165-9. doi: 10.1007/BF00404401.
The cytotoxic effect of bleomycin and peplomycin was compared using a methylcellulose monolayer assay for the cultivation of human tumor cells. In 3 out of 4 samples from human malignant melanomas peplomycin proved to be more cytotoxic than bleomycin. Peplomycin was more cytotoxic than bleomycin in 1 of 5 myosarcoma samples, whereas 2 samples from squamous cell carcinomas of the lung showed identical dose response curves. In 1 carcinoma of the gall bladder peplomycin was more toxic than bleomycin.
使用甲基纤维素单层试验培养人肿瘤细胞，比较了博来霉素和培普利霉素的细胞毒性作用。在来自人类恶性黑色素瘤的4个样本中，有3个样本显示培普利霉素比博来霉素的细胞毒性更强。在5个肉瘤样本中，有1个样本显示培普利霉素比博来霉素的细胞毒性更强，而来自肺鳞状细胞癌的2个样本显示出相同的剂量反应曲线。在1个胆囊癌样本中，培普利霉素比博来霉素的毒性更强。
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