Mental Health Sciences Unit, Faculty of Brain Sciences, University College London, United Kingdom.
Institute of Biomedical Research (IBSAL), Salamanca, Spain; Neuroscience Institute of Castilla y León, University of Salamanca, Salamanca, Spain.
Psychiatry Res. 2014 Jan 30;221(1):104-13. doi: 10.1016/j.pscychresns.2013.11.001. Epub 2013 Nov 17.
The cognitive deficit profile is different among individuals with schizophrenia. We quantified the amount of electroencephalographic activity unlocked to stimuli onset (noise power) over frontal regions regarding deficit in cognitive domains. Forty-six patients with schizophrenia and 27 healthy controls underwent clinical, cognitive and electrophysiological assessments. Noise power studies may be considered complementary but not equivalent to induced power studies. We compared gamma and theta noise power magnitude during a P300 paradigm between subsets of patients divided according to cognitive deficit in key domains and controls. Patients displayed higher gamma noise power activity at Fz site and significantly lower performance in all cognitive domains when compared to controls. The subset of patients with cognitive deficit for working memory and problem solving/executive functions domains displayed significantly higher frontal-lateral noise power values in comparison to the subset of patients without cognitive deficit and controls. Patients with significant cognitive deficits in domains with greater frontal contribution are also characterized by an abnormally higher gamma band noise power over the frontal region. Our data may endorse various biological subsets within schizophrenia, characterized by the presence or absence of a significant cognitive deficit in frontal domains.
精神分裂症患者的认知缺陷特征各不相同。我们量化了额叶区域对刺激起始的脑电图活动（噪声功率），以评估认知领域的缺陷。46 名精神分裂症患者和 27 名健康对照者接受了临床、认知和电生理评估。噪声功率研究可以被认为是补充性的，但与诱发功率研究并不等同。我们比较了根据关键认知领域缺陷和对照组划分的患者亚组在 P300 范式期间的伽马和 theta 噪声功率幅度。与对照组相比，患者在 Fz 部位的伽马噪声功率活动更高，并且在所有认知领域的表现均显著降低。与无认知缺陷的患者和对照组相比，在工作记忆和解决问题/执行功能领域存在认知缺陷的患者亚组显示出显著更高的额侧噪声功率值。在额叶贡献较大的领域存在显著认知缺陷的患者，其额叶区域的伽马波段噪声功率也异常升高。我们的数据可能支持精神分裂症中的各种生物学亚组，这些亚组的特征是存在或不存在额叶领域的显著认知缺陷。
