Neuroscience Institute of Castilla y León, School of Psychology, University of Salamanca, Salamanca, Spain; Biomedical Research Institute of Salamanca, Salamanca, Spain.
Psychiatry Clin Neurosci. 2014 Mar;68(3):206-15. doi: 10.1111/pcn.12120. Epub 2013 Dec 8.
The aim of this study was to assess the relation between cognition, gray matter (GM) volumes and gamma noise power (amount of background oscillatory activity in the gamma band) in schizophrenia.
We explored the relation between cognitive performance and regional GM volumes using voxel-based morphometry (VBM), in order to discover if the association between gamma noise power (an electroencephalography measurement of background activity in the gamma band) and cognition is observed through structural deficits related to the disease. Noise power, magnetic resonance imaging and cognitive assessments were obtained in 17 drug-free paranoid patients with schizophrenia and 13 healthy controls.
In comparison with controls, patients showed GM deficits at posterior cingulate (bilateral),left inferior parietal (supramarginal gyrus) and left inferior dorsolateral prefrontal regions. Patients exhibited a direct association between performance in working memory and right temporal (superior and inferior gyri) GM densities. They also displayed a negative association between right anterior cerebellum volume and gamma noise power at the frontal midline (Fz) site.
A structural deficit in the cerebellum may be involved in gamma activity disorganization in schizophrenia. Temporal structural deficits may relate to cognitive dysfunction in this illness.
本研究旨在评估精神分裂症患者认知功能、灰质体积和伽马噪声功率（伽马波段背景振荡活动的量）之间的关系。
我们使用基于体素的形态学（VBM）方法来探索认知表现与区域灰质体积之间的关系，以发现伽马噪声功率（脑电图测量的伽马波段背景活动）与认知之间的关联是否通过与疾病相关的结构缺陷来观察。在 17 名未经药物治疗的偏执型精神分裂症患者和 13 名健康对照者中获得了噪声功率、磁共振成像和认知评估。
与对照组相比，患者在后扣带回（双侧）、左顶下（缘上回）和左额下回背外侧前额叶区域表现出灰质体积减少。患者在工作记忆表现与右颞（上、下回）灰质密度之间表现出直接关联。他们还显示右前小脑体积与额中线（Fz）部位的伽马噪声功率呈负相关。
小脑的结构缺陷可能与精神分裂症中的伽马活动紊乱有关。颞叶结构缺陷可能与这种疾病的认知功能障碍有关。
