Tikka Sai Krishna, Parvez Nizamuddin, Nongpiur Arvind, Goyal Nishant, Sinha Vinod Kumar
KS Mani Center for Cognitive Neurosciences, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India ; Department of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India.
Department of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India.
J Pediatr Neurosci. 2014 Sep-Dec;9(3):234-6. doi: 10.4103/1817-1745.147575.
Children and adolescents with volatile solvent/inhalant dependence have neurocognitive deficits. The study aimed to explore resting state gamma activity, which is a marker of cognitive function, in children and adolescents with inhalant dependence. The study also investigated differences in gamma activity across groups differing in inhaled amounts.
Clinical and electroencephalographic (EEG) data were collected from nine patients with inhalant dependence. 30-50 Hz spectral power was calculated using Welch's averaged periodogram method. The data were analyzed using descriptive statistics, bi-variate correlation, and nonparametric Mann-Whitney U-test.
While significant positive correlation was found between duration of dependence and gamma spectral power in left frontal region, no significant differences were found on comparison of the groups on gamma spectral power.
A complex neurobiological interaction is involved in the synaptic modulation brought about by inhalant use and this could be understood by studying changes in EEG parameters especially gamma activity.
患有挥发性溶剂/吸入剂依赖的儿童和青少年存在神经认知缺陷。本研究旨在探索吸入剂依赖的儿童和青少年静息状态下的γ活动，这是认知功能的一个指标。该研究还调查了吸入量不同的各组之间γ活动的差异。
收集了9例吸入剂依赖患者的临床和脑电图（EEG）数据。使用 Welch 平均周期图法计算30 - 50Hz频谱功率。采用描述性统计、双变量相关性分析和非参数 Mann-Whitney U检验对数据进行分析。
虽然发现依赖持续时间与左额叶区域的γ频谱功率之间存在显著正相关，但在γ频谱功率方面，各组之间比较未发现显著差异。
吸入剂使用所带来的突触调制涉及复杂的神经生物学相互作用，通过研究脑电图参数尤其是γ活动的变化可以理解这一点。
