静电相互作用介导的酶降解法程序化纳米组装体的水解。

Programmed hydrolysis of nanoassemblies by electrostatic interaction-mediated enzymatic-degradation.

机构信息

Departments of Chemistry and Chemical Engineering, Texas A&M University, P. O. Box 30012, College Station, Texas 77842, USA.

出版信息

Chem Commun (Camb). 2014 Jan 28;50(8):968-70. doi: 10.1039/c3cc46013d.

DOI:10.1039/c3cc46013d

PMID:24301076

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4165354/

Abstract

Electrostatic interaction-mediated enzymatic-hydrolysis of poly(lactide)-containing nanoscale assemblies is described. At physiological pH, degradable core-shell morphologies with charged shells can readily attract or repel enzymes carrying opposite or similar charges, respectively.

摘要

静电相互作用介导的含聚乳酸纳米组装体的酶促水解被描述。在生理 pH 值下，带电荷壳的可降解核壳形态可以分别轻易地吸引或排斥带相反或相似电荷的酶。