Group of Biomolecular Nanotechnology, MESA(+) Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Adv Drug Deliv Rev. 2012 Jun 15;64(9):811-25. doi: 10.1016/j.addr.2012.01.005. Epub 2012 Jan 20.
New nanocarrier platforms based on natural biological building blocks offer great promises in revolutionalizing medicine. The usage of specific protein cage structures: virus-like particles (VLPs) for drug packaging and targetted delivery is summarized here. Versatile chemical and genetic modifications on the outer surfaces and inner cavities of VLPs facilitate the preparation of new materials that could meet the biocompatibility, solubility and high uptake efficiency requirements for drug delivery. A full evaluation on the toxicity, bio-distribution and immunology of these materials are envisaged to boost their application potentials.
基于天然生物构建块的新型纳米载体平台有望彻底改变医学。本文总结了利用特定蛋白质笼状结构：病毒样颗粒（VLPs）进行药物包装和靶向递送的方法。VLPs 外表面和内腔的多样化化学和遗传修饰有助于制备新材料，以满足药物递送的生物相容性、溶解性和高摄取效率要求。预计对这些材料的毒性、生物分布和免疫学进行全面评估，以提高其应用潜力。
