Singapore MIT Alliance for Research and Technology, BioSystems and Micromechanics, 1 CREATE Way, #04-13/14 Enterprise Wing, Singapore 138602, Singapore.
Lab Chip. 2014 Feb 7;14(3):459-62. doi: 10.1039/c3lc51160j.
We developed a computational model to predict oxygen levels in microfluidic plastic devices during cell culture. This model is based on experimental evaluation of oxygen levels. Conditions are determined that provide adequate oxygen supply to two cell types, hepatocytes and endothelial cells, either by diffusion through the plastic device, or by supplying a low flow rate of medium.
我们开发了一种计算模型，用于预测细胞培养过程中微流控塑料设备中的氧水平。该模型基于氧水平的实验评估。确定了通过塑料设备扩散或提供低流速培养基来为两种细胞类型（肝细胞和内皮细胞）提供足够氧气供应的条件。
