Pollack S, Cunningham-Rundles C, Good R A, Day N K
Postgrad Med J. 1986 Oct;62(732):939-42. doi: 10.1136/pgmj.62.732.939.
A patient with apparent X-linked agammaglobulinaemia was found to be inordinately susceptible to anaphylactoid reactions to intramuscular injections of gammaglobulin. The patient was found also to have low levels of C1 esterase inhibitor (C1 INH). The possibility that the C1 INH deficiency and in this patient, whether genetic or acquired, fostered the susceptibility to the production of anaphylactoid reactions after gammaglobulin injections urges further studies of the association of C1 INH deficiency and anaphylactoid reactions to gammaglobulin injections. The possibility that C1 INH levels like C1q levels may be low in hypogammaglobulinaemic patients as a consequence of increased catabolism of this regulator of the complement system when IgG levels are low is considered.
一名明显患有X连锁无丙种球蛋白血症的患者被发现对肌肉注射丙种球蛋白产生类过敏反应异常敏感。该患者还被发现C1酯酶抑制剂（C1 INH）水平较低。C1 INH缺乏，无论在该患者中是遗传性还是获得性的，是否会促使其在注射丙种球蛋白后易产生类过敏反应，这一可能性促使人们进一步研究C1 INH缺乏与丙种球蛋白注射后类过敏反应之间的关联。有人认为，由于当IgG水平较低时补体系统调节因子的分解代谢增加，低丙种球蛋白血症患者的C1 INH水平可能与C1q水平一样较低。
