Lim Sang Gyu, Han Kyungdo, Kim Hyun-Ah, Pyo Sung Woon, Cho Young-Sik, Kim Kyung-Soo, Yim Hyeon Woo, Lee Won-Chul, Park Yong Gyu, Park Yong-Moon
Graduate School of Public Health, The Catholic University of Korea, Seoul, Korea; Department of Dentistry, College of Medicine, The Catholic University of Korea, Seoul, Korea.
J Clin Periodontol. 2014 Feb;41(2):121-30. doi: 10.1111/jcpe.12196. Epub 2013 Dec 10.
Recent studies have proposed an association between periodontitis and metabolic abnormalities. We investigated the association between insulin resistance and periodontitis among Korean adults.
A cross-sectional analysis was conducted using the Korea National Health and Nutrition Examination Survey 2008-2010. A total of 16,720 non-diabetic subjects over 18 years old were evaluated (7060 men and 9660 women). Periodontal status was assessed by the Community Periodontal Index. Insulin resistance was measured using the homeostasis model assessment of insulin resistance (HOMA-IR). Participants in the highest and lowest quartile of HOMA-IR were defined as insulin-resistant and insulin-sensitive respectively.
The prevalence of periodontitis increased significantly with higher HOMA-IR quartiles in post-menopausal women (p for linear association = 0.019). Among post-menopausal women, participants in the highest quartile of HOMA-IR were significantly more likely to have periodontitis compared to those in the lowest quartile [adjusted odds ratio (OR), 1.47; 95% confidence interval (CI), 1.07-2.01]. Moreover, obese post-menopausal women showed an increased association between insulin resistance and periodontitis (adjusted OR, 1.92; 95% CI,1.29-2.87). However, this association was not found in men or pre-menopausal women.
Our results suggest that insulin resistance may be associated with periodontitis, especially when combined with obesity, among post-menopausal women in Korea.
近期研究提出牙周炎与代谢异常之间存在关联。我们调查了韩国成年人中胰岛素抵抗与牙周炎之间的关联。
使用2008 - 2010年韩国国家健康与营养检查调查进行横断面分析。共评估了16720名18岁以上的非糖尿病受试者(7060名男性和9660名女性)。牙周状况通过社区牙周指数进行评估。使用胰岛素抵抗稳态模型评估(HOMA - IR)来测量胰岛素抵抗。HOMA - IR最高和最低四分位数的参与者分别被定义为胰岛素抵抗者和胰岛素敏感者。
绝经后女性中,牙周炎的患病率随HOMA - IR四分位数的升高而显著增加(线性关联p = 0.019)。在绝经后女性中,HOMA - IR最高四分位数的参与者患牙周炎的可能性显著高于最低四分位数的参与者[调整后的优势比(OR)为1.47;95%置信区间(CI)为1.07 - 2.01]。此外,肥胖的绝经后女性中胰岛素抵抗与牙周炎之间的关联增强(调整后的OR为1.92;95%CI为1.29 - 2.87)。然而,在男性或绝经前女性中未发现这种关联。
我们的结果表明,在韩国绝经后女性中,胰岛素抵抗可能与牙周炎有关,尤其是与肥胖同时存在时。