Huang Jing, Zhang Dan, Li Hua, Zhang Yiyun, Long Tianxue, Guo Xiaojing, Cui Hangyu, Wei Zixuan, Zhao Jun, Li Mingzi, Wang Pangbo
School of Nursing, Peking University, Beijing, China.
School of Nursing, Shanxi Medical University, Taiyuan, China.
Front Endocrinol (Lausanne). 2025 May 19;16:1558692. doi: 10.3389/fendo.2025.1558692. eCollection 2025.
The relationship between the Triglyceride-Glucose (TyG) index and periodontitis remains unclear. This study aims to elucidate this relationship using data from two large population-based surveys.
Datasets from NHANES (2009-2014) and KNHANES (2007-2018, except for 2011) were utilized. We applied multivariate logistic regression, stratified analysis, restricted cubic splines (RCS), and subgroup analyses to examine the correlation between the TyG index and periodontitis risk. The predictive value of the TyG index was assessed using receiver operating characteristic (ROC) curves. Mediation analyses investigated variables mediating this relationship.
The NHANES and KNHANES cohorts included 2,511 and 16,239 participants with periodontitis, respectively. After adjusting for covariates, the TyG index was significantly associated with periodontitis risk (NHANES: OR 1.19, 95%CI: 1.07-1.34; Q2 vs. Q1, OR 1.20, 95% CI: 1.02-1.42; Q4 vs. Q1, OR 1.23, 95%CI: 1.02-1.49. KNHANES: OR 1.09, 95% CI: 1.05-1.13; Q4 vs. Q1, OR 1.09, 95%CI: 1.02-1.17, for trend = 0.025). RCS analyses revealed a nonlinear relationship. ROC curves indicated that the predictive values of the TyG index were 8.24 (NHANES) and 8.69 (KNHANES). Mediation analysis showed that inflammatory (alkaline phosphatase and white blood cell) and metabolic factors (vitamin D and high-density lipoprotein cholesterol) partially mediated this association.
The observational analysis reveals a significant association between the TyG index and the risk of periodontitis. Further studies are needed to clarify the underlying mechanisms.
甘油三酯-葡萄糖（TyG）指数与牙周炎之间的关系尚不清楚。本研究旨在利用两项基于人群的大型调查数据阐明这种关系。
使用了美国国家健康与营养检查调查（NHANES，2009 - 2014年）和韩国国家健康与营养检查调查（KNHANES，2007 - 2018年，2011年除外）的数据集。我们应用多因素逻辑回归、分层分析、限制立方样条（RCS）和亚组分析来检验TyG指数与牙周炎风险之间的相关性。使用受试者工作特征（ROC）曲线评估TyG指数的预测价值。中介分析研究了介导这种关系的变量。
NHANES和KNHANES队列分别包括2511名和16239名患有牙周炎的参与者。在调整协变量后，TyG指数与牙周炎风险显著相关（NHANES：优势比1.19，95%置信区间：1.07 - 1.34；第二四分位数与第一四分位数相比，优势比1.20，95%置信区间：1.02 - 1.42；第四四分位数与第一四分位数相比，优势比1.23，95%置信区间：1.02 - 1.49。KNHANES：优势比1.09，95%置信区间：1.05 - 1.13；第四四分位数与第一四分位数相比，优势比1.09，95%置信区间：1.02 - 1.17，趋势P值 = 0.025）。RCS分析显示存在非线性关系。ROC曲线表明TyG指数的预测值分别为8.24（NHANES）和8.69（KNHANES）。中介分析表明炎症（碱性磷酸酶和白细胞）和代谢因素（维生素D和高密度脂蛋白胆固醇）部分介导了这种关联。
观察性分析揭示了TyG指数与牙周炎风险之间存在显著关联。需要进一步研究以阐明其潜在机制。
