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作为淋病流行病学研究工具的血清型分布分析。

Analysis of serovar distribution as a tool in epidemiological studies in gonorrhoea.

作者信息

Rudén A K, Bäckman M, Bygdeman S, Jonsson A, Ringertz O, Sandström E

出版信息

Acta Derm Venereol. 1986;66(4):325-33.

PMID:2430404
Abstract

During one year 738 gonococcal isolates from 731 consecutive patients with gonorrhoea were collected and classified by co-agglutination using W I and W II/III specific monoclonal antibodies. Eight W I and 30 W II/III serovars (serovariants) were seen. In both serogroups the most frequent serovar among isolates from women and heterosexual men differed from that among isolates from homosexual men. Forty-two per cent of the serovars, were confined only to one subpopulation, i.e. women, heterosexual men or homosexual men, representing 19 (3%) of the 738 isolates. Out of these 19 isolates 42% were acquired abroad compared with 12% of the 653 isolates in the serovars shared between two or all three subpopulations (p less than 0.005). Imported W I isolates were often of the same serovar that dominated in Stockholm. W II/III isolates acquired abroad were often of unusual serovars (p less than 0.0005) and might be a source of future changes of the serovar pattern in Sweden. In this way we can follow the introduction of new serovars into our society and their circulation between the subpopulations.

摘要

在一年时间里,收集了731例连续淋病患者的738株淋球菌分离株,并使用W I和W II/III特异性单克隆抗体通过协同凝集进行分类。观察到8种W I血清型和30种W II/III血清型(血清变异型)。在这两个血清群中,女性和异性恋男性分离株中最常见的血清型与同性恋男性分离株中的不同。42%的血清型仅局限于一个亚群,即女性、异性恋男性或同性恋男性,占738株分离株中的19株(3%)。在这19株分离株中,42%是在国外获得的,而在两个或所有三个亚群共有的血清型中的653株分离株中这一比例为12%(p<0.005)。进口的W I分离株通常是在斯德哥尔摩占主导地位的相同血清型。在国外获得的W II/III分离株通常是不寻常的血清型(p<0.0005),可能是瑞典未来血清型模式变化的一个来源。通过这种方式,我们可以追踪新血清型引入我们的社会以及它们在亚群之间的传播情况。

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引用本文的文献

1
Temporal changes in the gonococcal serovar patterns in Stockholm during two years with special reference to PPNG strains.斯德哥尔摩两年间淋病菌血清型模式的时间变化,特别提及产青霉素酶淋球菌(PPNG)菌株。
Genitourin Med. 1994 Aug;70(4):256-61.
2
Serological classification of Neisseria gonorrhoeae. Clinical and epidemiological applications.淋病奈瑟菌的血清学分类。临床及流行病学应用。
Antonie Van Leeuwenhoek. 1987;53(6):375-80. doi: 10.1007/BF00415490.
3
Direct detection of Neisseria gonorrhoeae with monoclonal antibodies characterized by serotyping reagents.
采用以血清分型试剂为特征的单克隆抗体直接检测淋病奈瑟菌。
J Clin Microbiol. 1989 Jul;27(7):1700-3. doi: 10.1128/jcm.27.7.1700-1703.1989.
4
Current status of serotyping of Neisseria gonorrhoeae.淋病奈瑟菌血清分型的现状
Eur J Epidemiol. 1990 Mar;6(1):91-5. doi: 10.1007/BF00155558.