Knapp J S, Holmes K K, Bonin P, Hook E W
Sex Transm Dis. 1987 Jan-Mar;14(1):26-32.
The auxotype/serovar (A/S) class of 489 isolates of Neisseria gonorrhoeae were determined and 425 isolates from 390 consecutive patients with gonorrhea who attended the Sexually Transmitted Diseases Clinic at Harborview Medical Center in Seattle during the first three months of 1985 were analyzed. Patients included 123 women, 187 heterosexual men, and 80 homosexual men. A total of 57 A/S classes of N. gonorrhoeae were identified during this study. For the first eight weeks, between three and seven new A/S classes were identified each week. The number of new A/S classes encountered in this community declined subsequently, and leveled off at about zero to two new A/S classes introduced per week. Two A/S classes were limited almost solely to homosexual men, one group of related classes was limited to heterosexual patients, and one class was initially limited largely to heterosexual men, possibly because of spread from a prostitute. The results show that the A/S classification system can be used in combination with epidemiologic data for tracing the introduction and spread of gonoccocal strains and their eventual elimination from a community. A/S classification can be used to study the clinical epidemiology of gonorrhea and may facilitate evaluation of strategies for control of gonorrhea.
测定了489株淋病奈瑟菌的菌型/血清型（A/S）类别，并对1985年头三个月在西雅图港景医疗中心性病门诊就诊的390例连续性淋病患者的425株分离菌进行了分析。患者包括123名女性、187名异性恋男性和80名同性恋男性。在该研究期间共鉴定出57种淋病奈瑟菌的A/S类别。在最初的八周内，每周鉴定出三至七种新的A/S类别。该社区中遇到的新A/S类别的数量随后下降，并稳定在每周引入约零至两种新A/S类别。两种A/S类别几乎仅局限于同性恋男性，一组相关类别局限于异性恋患者，还有一种类别最初主要局限于异性恋男性，可能是由于一名妓女的传播。结果表明，A/S分类系统可与流行病学数据结合使用，以追踪淋病菌株的引入和传播以及它们最终从一个社区中消除的情况。A/S分类可用于研究淋病的临床流行病学，并可能有助于评估淋病控制策略。
