Bygdeman S, Danielsson D, Sandström E
Acta Pathol Microbiol Immunol Scand B. 1983 Oct;91(5):293-305.
A total of 849 gonococcal strains from 659 patients in Copenhagen (Denmark), Helsinki (Finland), Oslo and Trondheim (Norway) and Stockholm (Sweden) were included in the study. Using coagglutination reagents with polyclonal and monoclonal antibodies the strains were serogrouped into the previously described gonococcal serogroups W I, W II and W III. W II strains were dominating in all five towns (60.0%-70.9% of the strains), but W III strains were rarely isolated. W I strains were more frequent among women than among men. With the monoclonal reagents, W I, W II and W III strains could be further subdivided into 12, 29 and two different serovariants (serovars), respectively. One of the W I serovars was dominating (76%-94% of W I strains) in all five towns, and apart from this serovar, only three to five other W I serovars were seen in each town. Of W II strains, on the other hand, a greater variety of serovars were seen: between six in Trondheim and 17 in Oslo, and no one was dominating as among W I strains. Different W II serovar patterns were found in the different towns. Even between the two participating laboratories in each of the towns, Oslo and Helsinki, differences were noted. The epidemiological value of this is discussed. Ten of the 11 beta-lactamase-producing gonococcal strains isolated belonged to unusual serovars. None of the monoclonal coagglutination patterns corresponded to a single polyclonal pattern. There were, however, some relations between the two systems. In earlier studies it was shown that in smaller Swedish towns W I strains dominated. A hyphothesis about protective anti-Protein I antibodies is discussed to explain the differences in distribution of W I and W II strains between smaller and larger towns and between women and men.
该研究纳入了来自丹麦哥本哈根、芬兰赫尔辛基、挪威奥斯陆和特隆赫姆以及瑞典斯德哥尔摩659名患者的849株淋病菌株。使用含有多克隆和单克隆抗体的协同凝集试剂，这些菌株被血清分组为先前描述的淋病菌血清群W I、W II和W III。W II菌株在所有五个城市中占主导地位（占菌株的60.0%-70.9%），但W III菌株很少分离到。W I菌株在女性中比在男性中更常见。使用单克隆试剂，W I、W II和W III菌株可进一步分别细分为12、29和两种不同的血清变体（血清型）。W I血清型之一在所有五个城市中占主导地位（占W I菌株的76%-94%），除了这个血清型外，每个城市仅可见三到五种其他W I血清型。另一方面，W II菌株可见更多样化的血清型：在特隆赫姆有6种，在奥斯陆有17种，且没有一种像W I菌株那样占主导地位。在不同城市发现了不同的W II血清型模式。甚至在奥斯陆和赫尔辛基每个城市的两个参与实验室之间也注意到了差异。讨论了其流行病学价值。分离出的11株产β-内酰胺酶淋病菌株中有10株属于不寻常的血清型。没有一种单克隆协同凝集模式与单一的多克隆模式相对应。然而，这两个系统之间存在一些关系。在早期研究中表明，在瑞典较小的城镇中W I菌株占主导地位。讨论了一种关于保护性抗蛋白I抗体的假说，以解释W I和W II菌株在大小城镇之间以及男女之间分布的差异。
