Johansson O
Acta Physiol Scand. 1986 Oct;128(2):147-53. doi: 10.1111/j.1748-1716.1986.tb07961.x.
Neuropeptide Y (NPY)-like immunoreactivity has been found in autonomic nerve terminals and fibres of the normal human dermis by the use of indirect immunohistochemistry. Also a granular immunoreactivity was observed in the basal cells of the epidermis as well as in the cells of the outer root sheath of hair follicles. Thus, NPY should be considered when examining the role of different autonomic neurotransmitter candidates. Furthermore, NPY and norepinephrine may, at this level, serve together as co-transmitters or co-modulators of autonomic function. Finally, the immunoreactivity found in cells of the epidermis and the outer root sheath of hair follicles points to other functional effects so far not understood.
通过间接免疫组织化学方法，在正常人真皮的自主神经末梢和纤维中发现了神经肽Y（NPY）样免疫反应性。此外，在表皮基底细胞以及毛囊外根鞘细胞中也观察到颗粒状免疫反应性。因此，在研究不同自主神经递质候选物的作用时应考虑NPY。此外，在这一水平上，NPY和去甲肾上腺素可能共同作为自主神经功能的共同递质或共同调节剂。最后，在表皮细胞和毛囊外根鞘中发现的免疫反应性表明存在迄今尚未了解的其他功能效应。
