Kanter Y, Piell E, Santo M
Am J Gastroenterol. 1986 Nov;81(11):1043-7.
Hyperglucagonemia accompanies several disorders such as acute pancreatitis and diabetic ketoacidosis characterized by increased amylase/creatinine clearance ratio (ACCR). We tested the hypothesis that glucagon may be responsible for the augmental ACCR among diabetic and/or obese subjects. A constant glucagon infusion (15 ng/kg/min) was given to eight noninsulin-dependent diabetics and to eight obese subjects to attain glucagon levels comparable with those obtained during acute pancreatitis. The ACCR significantly increased from 0.9 +/- 0.1 to 1.5 +/- 0.1% (p less than 0.005) in both noninsulin-dependent diabetics and obese subjects, whereas among normal control subjects the ACCR increased from 0.84 +/- 0.8 to 1.3 +/- 0.14% (p less than 0.001). Because the increased values observed in either noninsulin-dependent diabetics or obese subjects are less than the ACCR values observed in acute pancreatitis or in diabetic ketoacidosis, the elevated ACCR in those conditions is only partially explained by the hyperglucagonemia.
高胰高血糖素血症伴随多种疾病，如急性胰腺炎和糖尿病酮症酸中毒，其特征为淀粉酶/肌酐清除率（ACCR）升高。我们检验了胰高血糖素可能是糖尿病和/或肥胖受试者ACCR升高原因的假设。对8名非胰岛素依赖型糖尿病患者和8名肥胖受试者持续输注胰高血糖素（15纳克/千克/分钟），以使胰高血糖素水平达到与急性胰腺炎期间相当的水平。非胰岛素依赖型糖尿病患者和肥胖受试者的ACCR均显著从0.9±0.1%增至1.5±0.1%（p<0.005），而正常对照受试者的ACCR从0.84±0.8%增至1.3±0.14%（p<0.001）。由于在非胰岛素依赖型糖尿病患者或肥胖受试者中观察到的升高值低于在急性胰腺炎或糖尿病酮症酸中毒中观察到的ACCR值，这些情况下ACCR升高仅部分由高胰高血糖素血症解释。
