Banzato C, Maffeis C, Maines E, Cavarzere P, Gaudino R, Fava C, Minuz P, Boner A, Antoniazzi F
Department of Life and Reproduction Sciences, Section of Pediatrics, University of Verona, Verona, Italy.
Department of Medicine, University of Verona, Verona, Italy.
J Hum Hypertens. 2014 Jun;28(6):360-6. doi: 10.1038/jhh.2013.122. Epub 2013 Dec 5.
In adults, low levels of vitamin D are associated with hypertension. The aim of this study was to evaluate the relationship between 24-h blood pressure (BP) patterns and vitamin D levels in obese children. We recorded anthropometric parameters, took blood samples for 25-hydroxivitamin D measurements and monitored ambulatory BP (ABP) in 32 obese children (male/female: 21/11, age 7-16 years). Subjects in the lower tertiles had higher homeostasis model assessment of insulin resistance, nighttime systolic and diastolic ABP, nighttime systolic and diastolic ABP load, 24-h ABP index and nighttime systolic and diastolic ABP index than those in the higher tertile. Vitamin D correlated negatively with 24-h and nighttime systolic ABP, 24-h systolic ABP load, nighttime systolic and diastolic ABP load, 24-h systolic ABP index and nighttime systolic ABP index. The percentage of subjects with pathological 24-h systolic BP (SBP) load, nighttime SBP load, nighttime diastolic BP (DBP) load, nighttime SBP index and nighttime DBP index increased progressively as the vitamin deficiency categories increased (χ(2)=10.26, P<0.05; χ(2)=16.34, P<0.01; χ(2)=10.23, P<0.05; χ(2)=10.38 and χ(2)=10.06, P <0.01). Low levels of vitamin D in obese children were associated with a higher BP burden, especially at night.
在成年人中，维生素D水平低与高血压有关。本研究的目的是评估肥胖儿童24小时血压（BP）模式与维生素D水平之间的关系。我们记录了人体测量参数，采集血样以测量25-羟基维生素D，并对32名肥胖儿童（男/女：21/11，年龄7 - 16岁）进行动态血压（ABP）监测。处于较低三分位数的受试者比处于较高三分位数的受试者具有更高的胰岛素抵抗稳态模型评估、夜间收缩压和舒张压ABP、夜间收缩压和舒张压ABP负荷、24小时ABP指数以及夜间收缩压和舒张压ABP指数。维生素D与24小时和夜间收缩压ABP、24小时收缩压ABP负荷、夜间收缩压和舒张压ABP负荷、24小时收缩压ABP指数以及夜间收缩压ABP指数呈负相关。随着维生素缺乏类别增加，24小时收缩压（SBP）负荷、夜间SBP负荷、夜间舒张压（DBP）负荷、夜间SBP指数和夜间DBP指数异常的受试者百分比逐渐增加（χ(2)=10.26，P<0.05；χ(2)=16.34，P<0.01；χ(2)=10.23，P<0.05；χ(2)=10.38和χ(2)=10.06，P<0.01）。肥胖儿童维生素D水平低与更高的血压负担相关，尤其是在夜间。
