Freie Universität Berlin, Institute of Chemistry and Biochemistry, Takustrasse 3, 14195 Berlin (Germany) http://www.polytree.de.
Angew Chem Int Ed Engl. 2014 Jan 3;53(1):49-51. doi: 10.1002/anie.201308619. Epub 2013 Dec 4.
Release on demand: The pH gradients between extra- and intracellular regions can be utilized for the controlled release of drugs and biological cargos from delivery systems. Biocompatible carrier systems with pH-cleavable units must fulfill many other criteria as well, for example, a long blood circulation time. This can be achieved by tailored micro- and nanocarriers based on macromolecular architectures or stable self-assembled systems.
细胞内外区域之间的 pH 梯度可用于控制从递药系统中释放药物和生物有效载荷。具有 pH 可裂解单元的生物相容载体系统还必须满足许多其他标准，例如，长的血液循环时间。这可以通过基于大分子结构的定制的微纳载体或稳定的自组装系统来实现。
