创伤性和手术出血的止血策略。
Hemostatic strategies for traumatic and surgical bleeding.
作者信息
Behrens Adam M, Sikorski Michael J, Kofinas Peter
机构信息
Fischell Department of Bioengineering, University of Maryland, 2330 Jeong H. Kim Engineering Building, College Park, Maryland, 20742.
出版信息
J Biomed Mater Res A. 2014 Nov;102(11):4182-94. doi: 10.1002/jbm.a.35052. Epub 2013 Dec 12.
Abstract
Wide interest in new hemostatic approaches has stemmed from unmet needs in the hospital and on the battlefield. Many current commercial hemostatic agents fail to fulfill the design requirements of safety, efficacy, cost, and storage. Academic focus has led to the improvement of existing strategies as well as new developments. This review will identify and discuss the three major classes of hemostatic approaches: biologically derived materials, synthetically derived materials, and intravenously administered hemostatic agents. The general class is first discussed, then specific approaches discussed in detail, including the hemostatic mechanisms and the advancement of the method. As hemostatic strategies evolve and synthetic-biologic interactions are more fully understood, current clinical methodologies will be replaced.
摘要
对新型止血方法的广泛关注源于医院和战场中未得到满足的需求。许多当前的商业止血剂未能满足安全性、有效性、成本和储存方面的设计要求。学术关注促使现有策略得到改进以及新的进展。本综述将识别并讨论三大类止血方法：生物衍生材料、合成衍生材料和静脉注射止血剂。首先讨论一般类别，然后详细讨论具体方法，包括止血机制和方法的进展。随着止血策略的发展以及对合成-生物相互作用的更全面理解，当前的临床方法将被取代。
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