Siddall J K, Shetty S D, Cooper E H
Clin Chem. 1986 Nov;32(11):2040-3.
We have compared the concentrations in serum of gamma-seminoprotein (gamma-SM) and prostate specific antigen (PSA), two antigens of prostatic origin that are synthesized independently of prostatic acid phosphatase (PAP, EC 3.1.3.2), to assess their potential in monitoring prostatic cancer. At presentation, 27/30 (90%) patients with metastases had a PSA concentration greater than 10 ng/mL, and 29/30 (97%) a gamma-SM concentration greater than 10 ng/mL; 21/61 (34%) with disease but without metastases had an abnormal content of PSA, and 23/61 (38%) an abnormal gamma-SM. Concentrations of PSA and gamma-SM were significantly correlated (r = 0.68, p less than 0.001). In 20 patients without metastases followed longitudinally, the median concentrations of gamma-SM, PSA, and PAP in the 13 patients who developed bony metastases or showed signs of local spreading of the tumor were 58 ng/mL, 34 ng/mL, and 2.1 U/L, respectively. The corresponding median values in the seven patients who remained clinically stable were 2.5 and 3.9 ng/mL, and 2.3 U/L. We conclude that either PSA or gamma-SM can warn of disease progression when PAP activities are still within normal limits.
我们比较了γ-精蛋白（γ-SM）和前列腺特异性抗原（PSA）在血清中的浓度，这两种前列腺来源的抗原独立于前列腺酸性磷酸酶（PAP，EC 3.1.3.2）合成，以评估它们在监测前列腺癌方面的潜力。就诊时，27/30（90%）有转移的患者PSA浓度大于10 ng/mL，29/30（97%）γ-SM浓度大于10 ng/mL；21/61（34%）有疾病但无转移的患者PSA含量异常，23/61（38%）γ-SM异常。PSA和γ-SM的浓度显著相关（r = 0.68，p < 0.001）。在20例无转移的患者中进行纵向随访，13例发生骨转移或出现肿瘤局部扩散迹象的患者中，γ-SM、PSA和PAP的中位浓度分别为58 ng/mL、34 ng/mL和2.1 U/L。7例临床保持稳定的患者中相应的中位值分别为2.5 ng/mL、3.9 ng/mL和2.3 U/L。我们得出结论，当PAP活性仍在正常范围内时，PSA或γ-SM均可提示疾病进展。
