INSERM UMR S_1109, Labex Transplantex, FMTS, Hôpitaux and Faculté de Médecine, Université de Strasbourg, 67085 Strasbourg Cedex and IRMA, CNRS UMR 7501, Labex IRMIA, Université de Strasbourg, 67084 Strasbourg Cedex, France.
Bioinformatics. 2014 Feb 15;30(4):571-3. doi: 10.1093/bioinformatics/btt705. Epub 2013 Dec 3.
Temporal gene interactions, in response to environmental stress, form a complex system that can be efficiently described using gene regulatory networks. They allow highlighting the more influential genes and spotting some targets for biological intervention experiments. Despite that many reverse engineering tools have been designed, the Cascade package is an integrated solution adding several new and original key features such as the ability to predict changes in gene expressions after a biological perturbation in the network and graphical outputs that allow monitoring the spread of a signal through the network.
The R package Cascade is available online at http://www-math.u-strasbg.fr/genpred/spip.php?rubrique4.
环境胁迫下的时空调控基因相互作用形成了一个复杂的系统，可以使用基因调控网络来有效地描述。这可以突出更有影响力的基因，并发现一些生物干预实验的目标。尽管已经设计了许多反向工程工具，但 Cascade 软件包是一个集成的解决方案，它增加了几个新的和原创的关键特性，例如能够预测网络中生物扰动后基因表达的变化，以及图形输出，允许监测信号在网络中的传播。
R 软件包 Cascade 可在线获得，网址为 http://www-math.u-strasbg.fr/genpred/spip.php?rubrique4。
