Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.
Expert Rev Proteomics. 2014 Feb;11(1):31-41. doi: 10.1586/14789450.2014.864953. Epub 2013 Nov 26.
Periodontitis is a common chronic and destructive disease whose pathogenetic mechanisms remain unclear. Due to their sensitivity and global scale, proteomics studies offer the opportunity to uncover critical host and pathogen activity indicators and can elucidate clinically applicable biomarkers for improved diagnosis and treatment of the disease. This review summarizes the literature of proteomics studies on periodontitis and comprehensively discusses commonly found candidate biomarkers. Key considerations in the design of an experimental proteomics platform are also outlined. The applicability of protein biomarkers across the progression of periodontitis and unexplored areas of research are highlighted.
牙周炎是一种常见的慢性、破坏性疾病，其发病机制尚不清楚。由于蛋白质组学研究具有敏感性和全球性，因此为揭示关键的宿主和病原体活性指标提供了机会，并可以阐明临床上可应用的生物标志物，以改善疾病的诊断和治疗。本综述总结了牙周炎蛋白质组学研究的文献，并全面讨论了常见的候选生物标志物。还概述了实验蛋白质组学平台设计中的关键考虑因素。强调了蛋白质生物标志物在牙周炎进展过程中的适用性和尚未探索的研究领域。
