Université François-Rabelais de Tours, EA 2106 'Biomolécules et Biotechnologies Végétales', Tours, France.
Université François-Rabelais de Tours, EA 2106 'Biomolécules et Biotechnologies Végétales', Tours, France.
Trends Biotechnol. 2014 Apr;32(4):167-8. doi: 10.1016/j.tibtech.2013.10.006. Epub 2013 Dec 2.
Some of the fungal CTG clade species represent attractive yeast models in many aspects of biotechnology. Their particular codon usage has hindered the development of genetic approaches for exploring and exploiting their biotechnological potential. CTG clade yeast biotechnology now benefits from the establishment of versatile molecular toolboxes. In addition, a large range of rapidly evolving genomic and postgenomic approaches has recently enhanced the understanding of the architecture of CTG species metabolic networks. These represent essential prerequisites for further successful development of metabolic engineering in CTG yeasts by facilitating the design of synthetic pathways.
一些真菌 CTG 支系物种在生物技术的许多方面代表了有吸引力的酵母模型。它们特殊的密码子使用情况阻碍了探索和利用其生物技术潜力的遗传方法的发展。CTG 支系酵母生物技术现在受益于多功能分子工具盒的建立。此外，最近大量快速进化的基因组和后基因组方法提高了对 CTG 物种代谢网络结构的理解。这些是通过促进合成途径的设计，进一步成功开发 CTG 酵母代谢工程的必要前提。
