Aktuğ Demir Nazlım, Çelik Mustafa, Kölgelier Servet, Sümer Sua, Aksöz Selçuk, Demir Lütfi Saltuk, İnkaya Ahmet Çağkan
Turk Psikiyatri Derg. 2013 Winter;24(4):248-52.
The aim of this study was to evaluate the relative contribution of chronic illness and the physical effects such illness on the mental status of chronic hepatitis B patients by comparing them to inactive hepatitis B carriers, based on Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS) scores.
The study included 444 participants: 249 HBsAg-positive inactive carriers (IC group) and 195 chronic hepatitis B patients (CH group) that were undergoing follow-up at Adiyaman University Research and Education Hospital, Department of Infectious Diseases Department. HBV carrier status and chronic hepatitis B were diagnosed based on European Association for the Study of Liver (EASL) guidelines. The HDRS and HARS were administered to all the participants via psychiatric interview.
The overall mean HDRS score was 6.2 ± 8 and the overall mean HARS score was 6.0 ± 7.1. Mean HDRS score in the IC group was 7.5 ± 5.8, versus 8.8 ± 6.6 in the CH group; the difference was significant (P = 0.037). Mean HARS score were similar in both groups (P > 0.05). There wasn't a difference in anxiety or depression scores based on participants'gender or age (P > 0.05). Additionally, there wasn't a correlation between duration of illness, and family history of hepatitis or cirrhosis, or anxiety or depression scores (P > 0.05). Anxiety scores were higher among the participants with comorbidity, in both CHB and IC groups (P= 0.005 and P = 0.001, respectively). Depression scores were higher among the IC group participants with comorbidity (P= 0.003). that can occur during the treatment and follow-up of chronic hepatitis patients. The presence of comorbidity in chronic hepatitis patients increases the risk of psychiatric complications.
Psychiatric comorbidity, particularly anxiety and depression, are important problems.
本研究旨在通过基于汉密尔顿抑郁量表（HDRS）和汉密尔顿焦虑量表（HARS）评分，将慢性乙型肝炎患者与非活动性乙型肝炎携带者进行比较，评估慢性病及其身体影响对慢性乙型肝炎患者心理状态的相对贡献。
该研究纳入了444名参与者：249名HBsAg阳性非活动性携带者（IC组）和195名在阿迪雅曼大学研究与教育医院传染病科接受随访的慢性乙型肝炎患者（CH组）。根据欧洲肝脏研究协会（EASL）指南诊断HBV携带者状态和慢性乙型肝炎。通过精神科访谈对所有参与者进行HDRS和HARS评估。
HDRS总平均分是6.2±8，HARS总平均分是6.0±7.1。IC组的HDRS平均分为7.5±5.8，而CH组为8.8±6.6；差异具有统计学意义（P = 0.037）。两组的HARS平均分相似（P>0.05）。基于参与者的性别或年龄，焦虑或抑郁评分没有差异（P>0.05）。此外，疾病持续时间、肝炎或肝硬化家族史与焦虑或抑郁评分之间没有相关性（P>0.05）。在合并症患者中，CHB组和IC组的焦虑评分均较高（分别为P = 0.005和P = 0.001）。IC组合并症患者的抑郁评分较高（P = 0.003）。这可能发生在慢性肝炎患者的治疗和随访期间。慢性肝炎患者合并症的存在增加了精神并发症的风险。
精神合并症，尤其是焦虑和抑郁，是重要问题。
