Zhang M, Xu W-D, Zhu Y, Wen P-F, Leng R-X, Pan H-F, Ye D-Q
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, PR China.
Anhui Provincial Laboratory of Population Health & Major Disease Screening and Diagnosis, Anhui Medical University, Hefei, Anhui, PR China.
Z Rheumatol. 2014 Apr;73(3):277-80. doi: 10.1007/s00393-013-1274-y.
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by abnormal production of autoantibodies and proinflammatory cytokines. The clear pathogenesis of SLE has not been fully elucidated. Cytokine-mediated immunity has been showed to be involved in the pathogenesis of SLE.
The aim of this study was to investigate serum levels of cytokines (IL-19, IL-24, IL-26, IL-31, IL-32, IL-36) in SLE patients, in comparison with normal controls in a Chinese population.
A total of 65 patients with SLE and 65 healthy volunteers were recruited for the current study. All serum levels of cytokines were measured by enzyme-linked immunosorbent assay (ELISA) kits.
Serum levels of IL-19, IL-24, IL-26, IL-31, IL-32 and IL-36 in SLE patients were not significantly different from the normal controls (all p > 0.05).
Serum levels of IL-19, IL-24, IL-26, IL-31, IL-32 and IL-36 in SLE patients were not markedly different from the normal controls. However, functional research should be discussed in future studies to elucidate the roles of these cytokines in SLE.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，其特征为自身抗体和促炎细胞因子产生异常。SLE确切的发病机制尚未完全阐明。细胞因子介导的免疫已被证明参与SLE的发病机制。
本研究旨在调查中国人群中SLE患者血清细胞因子（IL-19、IL-24、IL-26、IL-31、IL-32、IL-36）水平，并与正常对照进行比较。
本研究共招募了65例SLE患者和65名健康志愿者。所有细胞因子的血清水平均采用酶联免疫吸附测定（ELISA）试剂盒进行检测。
SLE患者血清IL-19、IL-24、IL-26、IL-31、IL-32和IL-36水平与正常对照无显著差异（所有p>0.05）。
SLE患者血清IL-19、IL-24、IL-26、IL-31、IL-32和IL-36水平与正常对照无明显差异。然而，未来研究应探讨功能研究以阐明这些细胞因子在SLE中的作用。
