Association of polymorphisms and the single nucleotide polymorphism rs2243188 with systemic lupus erythematosus.

OBJECTIVE

Abnormal B cell lymphoma-2 (Bcl-2) and interleukin-19 (IL-19) expression is closely related to systemic lupus erythematosus (SLE) pathogenesis. We aimed to determine whether polymorphisms and a single nucleotide polymorphism (SNP) of are significantly associated with SLE susceptibility and if this is affected by synergism between and genotypes.

METHODS

This observational cohort study randomly enrolled 150 patients with SLE and 150 healthy controls. Major and allele and genotype distributions were examined in the two groups. The SNP rs2243188 was determined using the TaqMan-MGB probe method. The synergistic effect between and and clinical symptoms of SLE was also analyzed.

RESULTS

The distribution of major genotypes and common alleles, especially for genotypes 191, 193, and 197, differed significantly between patients and controls. A significant difference in the dominant genetic model was also observed between groups, but not in the recessive model. The risk of disease in individuals who carried both 195-bp and 138-bp susceptibility alleles was higher than in those carrying either allele alone.

CONCLUSIONS

This preliminary study suggested that polymorphisms and the SNP rs2243188 are closely related to the pathogenesis of SLE.