Topcu Ismet, Vatansever Seda, Bayram Eda, Var Ahmet, Cetin Ismail, Civi Melek
Celal Bayar University, Faculty of Medicine, Department of Anesthesiology and Intensive Care, Manisa, Turkey.
Turk Neurosurg. 2013;23(6):764-71. doi: 10.5137/1019-5149.JTN.7749-13.0.
In this study, the effects of lornoxicam on the prevention of secondary brain injury via the apoptotic pathway were studied in a rat model of head injury.
Thirty adult male Wistar albino rats were anesthetized, and experimental closed head trauma was induced by allowing a 450 g weight to fall two meters onto a metallic disk fixed to the intact skull. After head injury, the rats were randomly divided into two groups: Group I (n=15) rats were administered 2 mL saline intraperitoneally (controls); Group II (n=15) rats were administered 2 mL 1.3 mg kg-1 lornoxicam intraperitoneally. Brain tissue samples were divided into two pieces by interhemispheric incision for biochemical and histological analysis.
TUNEL positivity was seen in neuroglia cells of the brain cortex in both groups. While the immunoreactivities of caspase 8, 9 and Fas/ Fas ligand were similar in both groups, the immunoreactivity of caspase 3 was greater in Group I than Group II. MDA was significantly lower in Group II than in Group I (p < 0.05). The decrease in SOD level was higher in Group I than Group II.
Lornoxicam did not prevent apoptosis in this rat model of brain trauma but causes a decrease.
