Department of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742 (South Korea).
Angew Chem Int Ed Engl. 2014 Jan 20;53(4):924-6. doi: 10.1002/anie.201309201. Epub 2013 Dec 6.
Hexacyclic framework: The total synthesis of the complex C18 -norditerpenoid alkaloid neofinaconitine has been achieved by a convergent approach. This remarkable synthesis featured two Diels-Alder cycloadditions and subsequent Mannich-type N-acyliminium and radical cyclizations to establish the unique hexacyclic core structure of the target molecule.
通过汇聚方法实现了复杂的 C18-降二萜生物碱新福林辛因的全合成。这个引人瞩目的合成方法采用了两次 Diels-Alder 环加成反应，以及随后的 Mannich 型 N-酰亚胺鎓和自由基环化反应，从而构建了目标分子独特的六元环核心结构。
