Department of Entomology, University of Illinois at Urbana-Champaign, 61801-3795, Urbana, IL.
J Chem Ecol. 1985 Oct;11(10):1349-58. doi: 10.1007/BF01012136.
Myristicin, a methylenedioxyphenyl (MDP)-containing phenylpropene constituent of the leaves of many plants in the family Umbelliferae, is a highly effective Synergist of the cooccurring furanocoumarin xanthotoxin. As little as 0.10 % in an artificial diet can increase the toxicity of xanthotoxin toHeliothis zea (Lepidotera: Noctuidae) fivefold. In addition to increasing the proportion of caterpillars dying at a given xanthotoxin concentration, myristicin also increases the rate at which they die and increases the time to molt of surviving larvae. That there was no increase in the deterrency of xanthotoxin in the presence of myristicin suggests that the mechanism of synergism is not behaviorial but rather is biochemical, via MDP competitive inhibition of microsomal mixed function oxidases.
肉豆蔻醚，一种含亚甲二氧基苯（MDP）的苯丙烯成分，存在于伞形科植物的叶子中，是共同存在的呋喃香豆素黄曲霉素的高效增效剂。在人工饲料中，只需添加 0.10%的肉豆蔻醚就可以使黄曲霉素对玉米夜蛾（鳞翅目：夜蛾科）的毒性增加五倍。除了增加在给定黄曲霉素浓度下死亡的毛毛虫的比例外，肉豆蔻醚还会增加它们死亡的速度，并增加存活幼虫蜕皮的时间。在肉豆蔻醚存在的情况下，黄曲霉素的驱避性没有增加，这表明增效作用的机制不是行为性的，而是生物化学性的，通过 MDP 竞争性抑制微粒体混合功能氧化酶。
