Delgado-Bogotá Natalia V, Patiño-Ladino Oscar J, Prieto-Rodríguez Juliet A
Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Sede Bogotá, Bogotá 111321, Colombia.
Departamento de Química, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá 110231, Colombia.
Plants (Basel). 2025 Aug 13;14(16):2514. doi: 10.3390/plants14162514.
, the causal agent of moniliasis, severely affects cacao production in Latin America, and sustainable control alternatives remain limited. This study aimed to evaluate the antifungal potential of essential oils (EOs) from species and selected volatile compounds against . A total of 34 EOs obtained by steam distillation were assessed for mycelial growth inhibition under fumigation conditions. The most active EOs (≥60% inhibition) were chemically characterized by GC-MS, and their median inhibitory concentrations (IC) were determined. Additionally, 40 structurally diverse volatile compounds were selected and evaluated for their antifungal activity to identify the main contributors and explore structure-activity relationships. Most of the active EOs exhibited a high proportion of phenylpropanoids and oxygenated monoterpenoids, with IC values ranging from 0.58 to 184.27 µL·L; the most active were those from and . Among the 28 most active compounds, IC values ranged from 0.48 to 109.81 µL·L; the most potent were myristicin and dillapiole. The most potent molecules were phenylpropanoids bearing methoxy and methylenedioxy groups, followed by oxygenated monoterpenoids and long-chain ketones. This is the first report of antifungal activity against for most of the evaluated EOs and all tested compounds, highlighting the potential of the genus as a source of natural alternatives for sustainable disease management in cacao cultivation.
念珠菌病的病原体严重影响拉丁美洲的可可生产，而可持续的防治方法仍然有限。本研究旨在评估来自[物种名称]的精油（EOs）和选定的挥发性化合物对[病原体名称]的抗真菌潜力。通过水蒸气蒸馏获得的总共34种EOs在熏蒸条件下评估其对菌丝生长的抑制作用。通过气相色谱 - 质谱联用（GC - MS）对活性最高的EOs（抑制率≥60%）进行化学表征，并测定其半数抑制浓度（IC）。此外，选择40种结构多样的挥发性化合物并评估其抗真菌活性，以确定主要贡献成分并探索构效关系。大多数活性EOs表现出高比例的苯丙素类和氧化单萜类，IC值范围为0.58至184.27 μL·L；活性最高的是来自[植物名称1]和[植物名称2]的EOs。在28种活性最高的化合物中，IC值范围为0.48至109.81 μL·L；最有效的是肉豆蔻醚和莳萝脑。最有效的分子是带有甲氧基和亚甲二氧基的苯丙素类，其次是氧化单萜类和长链酮。这是大多数评估的EOs和所有测试化合物对[病原体名称]抗真菌活性的首次报道，突出了[植物属名称]属作为可可种植中可持续病害管理天然替代品来源的潜力。
