通过邻氨基酚和苯胺与铁氰化物的氧化偶联实现温和的生物缀合。
Mild bioconjugation through the oxidative coupling of ortho-aminophenols and anilines with ferricyanide.
机构信息
Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720-1460 (USA).
出版信息
Angew Chem Int Ed Engl. 2014 Jan 20;53(4):1057-61. doi: 10.1002/anie.201307386. Epub 2013 Dec 5.
PMID:24311449
Abstract
Using a small-molecule-based screen, ferricyanide was identified as a mild and efficient oxidant for the coupling of anilines and o-aminophenols on protein substrates. This reaction is compatible with thiols and 1,2-diols, allowing its use in the creation of complex bioconjugates for use in biotechnology and materials applications.
摘要
利用基于小分子的筛选方法，发现铁氰化钾是一种温和且高效的氧化剂，可用于在蛋白质底物上偶联苯胺和邻氨基酚。该反应与硫醇和 1,2-二醇兼容，允许其用于创建复杂的生物缀合物，用于生物技术和材料应用。
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