加拿大的肿瘤生育力保护：性腺保护和生育力保存策略。
Oncofertility in Canada: gonadal protection and fertility-sparing strategies.
机构信息
Department of Obstetrics and Gynecology, Queen's University, Kingston, ON.
出版信息
Curr Oncol. 2013 Dec;20(6):e602-7. doi: 10.3747/co.20.1359.
BACKGROUND
Cancer can be a devastating diagnosis. In particular, malignancy and its indicated treatments have profoundly negative effects on the fertility of young cancer patients. Oncofertility has emerged as a new interdisciplinary field to address the issue of gonadotoxicity associated with cancer therapies and to facilitate fertility preservation. In Canada, fertility issues are often inadequately addressed despite the availability of resources. The goal of this four-part series is to facilitate systemic improvements in fertility preservation for adolescent and young adult Canadians with a new diagnosis of cancer.
METHODS
Here, we review the fertility preservation measures currently available. Medical and surgical strategies are both outlined.
RESULTS
Fertility-preserving strategies and gonadal protection have demonstrated variable success in a number of approaches. The value of hormone suppression is still in question for women. Progestins for endometrial cancer and alternative chemotherapies are other medical approaches. Gonadal shielding and protective surgical approaches have also been attempted.
CONCLUSIONS
The techniques discussed here may be selectively considered and integrated into patient care in an attempt to preserve future fertility before initiating cancer treatment.
背景
癌症可能是一个毁灭性的诊断。特别是恶性肿瘤及其治疗方法对年轻癌症患者的生育能力有深远的负面影响。肿瘤生育学作为一个新的跨学科领域应运而生，旨在解决癌症治疗相关的性腺毒性问题，并促进生育力保存。在加拿大，尽管有资源可用，但生育问题往往得不到充分解决。本系列文章共四部分，旨在为新诊断为癌症的青少年和年轻成年加拿大人提供生育力保存方面的系统改进。
方法
在这里，我们回顾了目前可用的生育力保存措施。概述了医疗和手术策略。
结果
在许多方法中，生育力保存策略和性腺保护都取得了不同程度的成功。对于女性来说，激素抑制的价值仍存在争议。孕激素用于子宫内膜癌和替代化疗是其他医学方法。性腺屏蔽和保护手术方法也已经尝试过。
结论
这里讨论的技术可以有选择地考虑，并在开始癌症治疗前整合到患者护理中，以尝试保存未来的生育能力。
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