Department of Obstetrics and Gynecology, Queen's University, Kingston, ON.
Curr Oncol. 2013 Aug;20(4):e338-44. doi: 10.3747/co.20.1358.
Cancer can be a devastating diagnosis. In particular, malignancy and its indicated treatments have profoundly negative effects on the fertility of young cancer patients. Oncofertility has emerged as a new interdisciplinary field to address the issue of gonadotoxicity associated with cancer therapies and to facilitate fertility preservation. In Canada, these fertility issues are often inadequately addressed despite the availability of resources. The goal of this four-part series is to facilitate systemic improvements in fertility preservation for adolescent and young adult Canadians with a new diagnosis of cancer.
In this article, we review the gonadotoxic effects of cancer treatment on young men and women of reproductive age.
The detrimental effects of cancer on fertility can be severe and may vary depending on the chemotherapy, radiotherapy, or surgical treatments involved.
Fertility preservation should be addressed in an effort to mitigate the gonadal damage that may come with cancer therapy.
癌症可能是一个毁灭性的诊断。特别是，恶性肿瘤及其治疗方法对年轻癌症患者的生育能力有深远的负面影响。肿瘤生育学作为一个新的跨学科领域出现，旨在解决与癌症治疗相关的性腺毒性问题，并促进生育力保存。在加拿大，尽管有资源，但这些生育问题往往没有得到充分解决。本系列文章共四部分，旨在为新诊断患有癌症的青少年和年轻成年加拿大人提供生育力保存方面的系统改进。
在本文中，我们回顾了癌症治疗对生育期男女的性腺毒性作用。
癌症对生育力的不利影响可能很严重，并且可能因所涉及的化疗、放疗或手术治疗而有所不同。
应该解决生育力保存问题，以减轻癌症治疗可能带来的性腺损伤。
